The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
Heart Center, Department of Cardiovascular Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Channels (Austin). 2023 Dec;17(1):2281743. doi: 10.1080/19336950.2023.2281743. Epub 2023 Nov 20.
Cardiovascular disease, especially heart failure (HF) is the leading cause of death in patients with diabetes. Individuals with diabetes are prone to a special type of cardiomyopathy called diabetic cardiomyopathy (DCM), which cannot be explained by heart diseases such as hypertension or coronary artery disease, and can contribute to HF. Unfortunately, the current treatment strategy for diabetes-related cardiovascular complications is mainly to control blood glucose levels; nonetheless, the improvement of cardiac structure and function is not ideal. The transient receptor potential cation channel subfamily V member 1 (TRPV1), a nonselective cation channel, has been shown to be universally expressed in the cardiovascular system. Increasing evidence has shown that the activation of TRPV1 channel has a potential protective influence on the cardiovascular system. Numerous studies show that activating TRPV1 channels can improve the occurrence and progression of diabetes-related complications, including cardiomyopathy; however, the specific mechanisms and effects are unclear. In this review, we summarize that TRPV1 channel activation plays a protective role in the heart of diabetic models from oxidation/nitrification stress, mitochondrial function, endothelial function, inflammation, and cardiac energy metabolism to inhibit the occurrence and progression of DCM. Therefore, TRPV1 may become a latent target for the prevention and treatment of diabetes-induced cardiovascular complications.
心血管疾病，特别是心力衰竭（HF）是糖尿病患者死亡的主要原因。糖尿病患者易患一种特殊类型的心肌病，称为糖尿病心肌病（DCM），它不能用高血压或冠状动脉疾病等心脏病来解释，并可导致 HF。不幸的是，目前治疗糖尿病相关心血管并发症的策略主要是控制血糖水平；然而，对心脏结构和功能的改善并不理想。瞬时受体电位阳离子通道亚家族 V 成员 1（TRPV1），一种非选择性阳离子通道，已被证明在心血管系统中普遍表达。越来越多的证据表明，TRPV1 通道的激活对心血管系统具有潜在的保护作用。许多研究表明，激活 TRPV1 通道可以改善与糖尿病相关的并发症的发生和进展，包括心肌病；然而，具体的机制和作用尚不清楚。在这篇综述中，我们总结了 TRPV1 通道的激活从氧化/硝化应激、线粒体功能、内皮功能、炎症和心脏能量代谢等方面在糖尿病模型的心脏中发挥保护作用，以抑制 DCM 的发生和进展。因此，TRPV1 可能成为预防和治疗糖尿病引起的心血管并发症的潜在靶点。
