Poliakova A M, Buriakovskaia L I, Astrina O S, Lomazova Kh D, Maleev V V
Ter Arkh. 1986;58(10):38-42.
Blood coagulation was studied in 19 patients with generalized meningococcal infection complicated by toxico-infectious shock (TIS). The outcomes were fatal in 42% of cases. Blood coagulation studies were done on days 1, 2, 3, 5-7 and 19-21 of treatment. Blood coagulability was found to be reduced drastically at the peak of disease: platelet aggregability was depressed substantially, and platelet secretory function showed profound disorders. The recovery of both plasma and platelet parameters of blood coagulation was rather slow. The magnitude of disorders may have a predictive value for the prognosis of the disease.
对19例伴有中毒性感染性休克（TIS）的全身性脑膜炎球菌感染患者的凝血情况进行了研究。42%的病例预后不良。在治疗的第1、2、3、5 - 7天以及第19 - 21天进行了凝血研究。结果发现，在疾病高峰期凝血能力急剧下降：血小板聚集性显著降低，血小板分泌功能出现严重紊乱。血浆和血小板凝血参数的恢复相当缓慢。紊乱的程度可能对疾病预后具有预测价值。
