Maleev V V, Poliakova A M, Astrina O S, Lomazova K D
Vestn Akad Med Nauk SSSR. 1991(10):4-8.
Platelets play the leading role in circulatory disorders seen in patients with infectious diseases. Endotoxinemia leads to platelet activation which shows up by the transformation of platelet forms from disk-shaped to spheroidal and by changes in aggregation and secretion. The degree of those changes correlates with the disease gravity. Experimental endotoxinemia (in vivo and in vitro experiments) demonstrated the same changes in the morphofunctional properties of platelets together with a possibility of correcting circulatory disorders by blockers of prostaglandin biosynthesis, such as indomethacin++, trental and emoxipine.
血小板在传染病患者出现的循环系统紊乱中起主要作用。内毒素血症导致血小板活化，表现为血小板形态从盘状转变为球状，以及聚集和分泌的变化。这些变化的程度与疾病严重程度相关。实验性内毒素血症（体内和体外实验）表明血小板的形态功能特性出现相同变化，同时使用前列腺素生物合成阻滞剂，如消炎痛、曲克芦丁和莫西普利，有可能纠正循环系统紊乱。
