Ring M E, Corrigan J J, Fenster P E
Thromb Res. 1986 Nov 1;44(3):391-400. doi: 10.1016/0049-3848(86)90013-7.
The effects of 3 days of oral diltiazem, "low dose" aspirin (40 mg/day), and their combination on platelet function was studied in 5 normal subjects. Both drugs inhibited platelet aggregation and ATP release induced by collagen, epinephrine and threshold concentrations of ADP. Aspirin and diltiazem decreased thromboxane A2 generation during ADP induced aggregation by 94 percent and 53 percent respectively, however both agents inhibited aggregation similarly, which suggests that diltiazem's anti-platelet effect was due to mechanisms other than inhibition of thromboxane metabolism alone. Combination therapy resulted in a partially additive inhibitory effect on ADP induced aggregation and thromboxane A2 generation. Two subjects had bleeding times over 15 minutes after receiving combination therapy.
在5名正常受试者中研究了口服地尔硫䓬3天、“低剂量”阿司匹林（40毫克/天）及其联合用药对血小板功能的影响。两种药物均抑制胶原、肾上腺素和阈浓度ADP诱导的血小板聚集和ATP释放。阿司匹林和地尔硫䓬分别使ADP诱导聚集过程中血栓素A2的生成减少94%和53%，然而两种药物对聚集的抑制作用相似，这表明地尔硫䓬的抗血小板作用并非仅归因于抑制血栓素代谢。联合治疗对ADP诱导的聚集和血栓素A2生成产生部分相加的抑制作用。两名受试者在接受联合治疗后出血时间超过15分钟。
