从细菌到生物医学：利用 NAD 代谢开发治疗方法。
From bacteria to biomedicine: Developing therapies exploiting NAD metabolism.
机构信息
Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, Zhejiang, China.
Molecular Microbiology & Immunology, School of Medicine, Oregon Health & Science University, Portland, OR, USA.
出版信息
Bioorg Chem. 2024 Jan;142:106974. doi: 10.1016/j.bioorg.2023.106974. Epub 2023 Nov 15.
Nicotinamide adenine dinucleotide (NAD) serves as a critical cofactor in cellular metabolism and redox reactions. Bacterial pathways rely on NAD participation, where its stability and concentration govern essential homeostasis and functions. This review delves into the role and metabolic regulation of NAD in bacteria, highlighting its influence on physiology and virulence. Notably, we explore enzymes linked to NAD metabolism as antibacterial drug targets and vaccine candidates. Moreover, we scrutinize NAD's medical potential, offering insights for its application in biomedicine. This comprehensive assessment informs future research directions in the dynamic realm of NAD and its biomedical significance.
烟酰胺腺嘌呤二核苷酸（NAD）在细胞代谢和氧化还原反应中充当关键辅酶。细菌途径依赖 NAD 的参与，其稳定性和浓度决定了必要的动态平衡和功能。本综述深入探讨了 NAD 在细菌中的作用和代谢调控，强调了其对生理学和毒力的影响。值得注意的是，我们研究了与 NAD 代谢相关的酶，将其作为抗菌药物靶点和疫苗候选物。此外，我们还仔细研究了 NAD 在医学上的潜力，为其在生物医学中的应用提供了见解。这项全面评估为 NAD 的动态领域及其在生物医学中的重要意义提供了未来的研究方向。
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