2010年至2022年中国口蹄疫病毒的流行病学和遗传特征

Epidemiological and genetic characteristics of foot-and-mouth disease virus in China from 2010 to 2022.

作者信息

Ren Xujiao, Li Pengfei, Li Xiangmin, Qian Ping

机构信息

National Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, Huazhong Agricultural University, Wuhan, 430070, Hubei, China; College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, Hubei, China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, Hubei, China; CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, 100101, China.

出版信息

Virology. 2024 Jan;589:109940. doi: 10.1016/j.virol.2023.109940. Epub 2023 Nov 11.

DOI:10.1016/j.virol.2023.109940

PMID:37984153

Abstract

Foot-and-mouth disease virus (FMDV) is a highly contagious picornavirus that can infect cloven-hoofed animals of significant agricultural importance. In China, foot-and-mouth disease (FMD) epidemics occur annually, resulting in localized outbreaks or sporadic epidemics that cause significant economic losses. This study summarized 123 cases of FMD reported in China between 2010 and 2022, using data from the official website of the Chinese Center for Animal Disease Control and Prevention. The epidemic situation and genetic characteristics of FMDV in China were studied through phylogenetic analysis, amino acid variation analysis of antigenic epitopes, and genetic recombination analysis. The findings provide important references for predicting the FMDV epidemic situation in China, developing vaccines, and effectively preventing and controlling FMD.

摘要

口蹄疫病毒（FMDV）是一种高度传染性的小核糖核酸病毒，可感染对农业具有重要意义的偶蹄类动物。在中国，口蹄疫（FMD）疫情每年都会发生，导致局部暴发或散发性流行，造成重大经济损失。本研究利用中国动物疫病预防控制中心官方网站的数据，总结了2010年至2022年间中国报告的123例口蹄疫病例。通过系统发育分析、抗原表位氨基酸变异分析和基因重组分析，研究了中国口蹄疫病毒的流行情况和遗传特征。研究结果为预测中国口蹄疫病毒流行情况、开发疫苗以及有效预防和控制口蹄疫提供了重要参考。