University of Greifswald, Department of Pharmacy, Institute of Biopharmaceutics and Pharmaceutical Technology, Center of Drug Absorption and Transport (C_DAT), Felix-Hausdorff-Straße 3, 17489 Greifswald, Germany.
University of Greifswald, Department of Pharmacy, Institute of Biopharmaceutics and Pharmaceutical Technology, Center of Drug Absorption and Transport (C_DAT), Felix-Hausdorff-Straße 3, 17489 Greifswald, Germany.
Int J Pharm. 2024 Jan 5;649:123628. doi: 10.1016/j.ijpharm.2023.123628. Epub 2023 Nov 19.
Administration of medications via enteral feeding tubes (EFTs) is a common practice for children who cannot swallow properly. Although liquid formulations are the preferred dosage forms for this route of administration, little attention has been paid to the amount of drug that reaches the site of absorption after administration via an EFT. This systematic in vitro study aimed to identify formulation parameters and administration approaches that are critical for successful dose delivery via EFTs. For this purpose, drug recovery after administration of three different paediatric ibuprofen suspensions via different types of EFTs was studied using derivative UV spectrophotometry for quantification. Study results indicate that in addition to formulation parameters, feeding tube characteristics and the administration process can have a significant impact on the administered dose. The ratio between the total administered fluid volume (TAV), represented by the sum of dose- and flushing volume, and the feeding tube volume (FTV) proved to be a valuable indicator for assessing successful administration. Incorrect dosing and complications could be avoided if the TAV/FTV ratio was greater than 4. This and other knowledge gained in the study will help to make the administration of liquid paediatric medicines via EFTs both more effective and safer.
经肠饲管（EFT）给药是不能正常吞咽的儿童的常见治疗方法。尽管液体剂型是该给药途径的首选剂型，但很少关注通过 EFT 给药后到达吸收部位的药物量。这项系统的体外研究旨在确定制剂参数和给药方法，这些参数和方法对于通过 EFT 成功给药至关重要。为此，使用衍生紫外分光光度法进行定量，研究了通过不同类型的 EFT 给予三种不同小儿布洛芬混悬剂后的药物回收情况。研究结果表明，除了制剂参数外，饲管特性和给药过程对给予的剂量有重大影响。总给予液量（TAV）与给予剂量和冲洗量之和与饲管体积（FTV）之间的比例被证明是评估成功给药的有价值指标。如果 TAV/FTV 比值大于 4，则可以避免给药错误和并发症。如果能够获得这些知识，将有助于提高通过 EFT 给予小儿液体药物的有效性和安全性。
