血清尿酸和痛风对结直肠癌发病率的影响：一项荟萃分析。

Effect of serum uric acid and gout on the incidence of colorectal cancer: A meta-analysis.

机构信息

Department of General Practice, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, PR China; Department of General Practice, Affiliated Hospital of Guilin Medical University, Guilin 541001, PR China.

Department of General Practice, The Second Affiliated Hospital of Guangxi Medical University, Nanning 530007, PR China.

出版信息

Am J Med Sci. 2024 Feb;367(2):119-127. doi: 10.1016/j.amjms.2023.11.013. Epub 2023 Nov 19.

DOI:10.1016/j.amjms.2023.11.013

PMID:37984737

Abstract

OBJECTIVE

Pathogenesis of colorectal cancer (CRC) depends on multiple factors. Identifying risk factors for CRC may facilitate the early prevention of the disease. We aimed to assess whether existing evidence suggests that serum uric acid (SUA) levels and gout are associated with CRC incidence.

METHODS

The study was registered on PROSPERO (CRD42022371591). Searches of PubMed, Embase, and Cochrane Library were conducted from the establishment to November 11, 2022. Pooled relative risk (RR) with 95 % confidence intervals (CI) was derived to evaluate the effect of SUA or gout on CRC incidence. Non-linear trend analysis was conducted to explore the relationship between SUA level and CRC incidence.

RESULTS

Twelve eligible studies with 22 reports were included. A meta-analysis of the included studies showed that when the highest and lowest SUA level categories were compared, an association between SUA level and CRC incidence was revealed (RR, 1.35; 95 % CI: 1.27-1.43; P < 0.001). Non-linear relationship between SUA level and CRC incidence was found. Further meta-analysis indicated that gout was associated with CRC incidence (RR, 1.22; 95 % CI: 1.08-1.36; P = 0.001).

CONCLUSIONS

Both SUA level and gout were associated with an increased risk of CRC. Maintaining low SUA levels may be beneficial in reducing the incidence of CRC. Further studies evaluating the precise mechanisms underlying this association are needed to establish whether SUA/gout causes CRC.

摘要

目的

结直肠癌（CRC）的发病机制取决于多种因素。确定 CRC 的危险因素可能有助于早期预防该疾病。我们旨在评估现有的证据是否表明血清尿酸（SUA）水平和痛风与 CRC 的发病率有关。

方法

该研究已在 PROSPERO（CRD42022371591）上注册。从建立到 2022 年 11 月 11 日，对 PubMed、Embase 和 Cochrane Library 进行了检索。得出汇总相对风险（RR）及其 95%置信区间（CI），以评估 SUA 或痛风对 CRC 发病率的影响。进行非线性趋势分析以探讨 SUA 水平与 CRC 发病率之间的关系。

结果

纳入了 12 项研究，共包含 22 项报告。对纳入研究的荟萃分析表明，当比较最高和最低 SUA 水平类别时，SUA 水平与 CRC 发病率之间存在关联（RR，1.35；95%CI：1.27-1.43；P<0.001）。发现 SUA 水平与 CRC 发病率之间存在非线性关系。进一步的荟萃分析表明，痛风与 CRC 发病率相关（RR，1.22；95%CI：1.08-1.36；P=0.001）。