Department of General Surgery, Aerospace Center Hospital, Yuquan Road 13, Haidian District, Beijing, 100038, China.
Department of Gastrointestinal Surgery/Clinical Nutrition, Capital Medical University Affiliated Beijing Shijitan Hospital, Beijing, 100038, China.
Sci Rep. 2022 Oct 6;12(1):16677. doi: 10.1038/s41598-022-20357-7.
Serum uric acid (SUA) may play an important role in the occurrence of colorectal cancer (CRC). This study aims to explore the association of SUA with the risk of CRC incidence by drawing data from the Kailuan Study. We prospectively examined the association between SUA and risk of CRC incidence among 93,356 Chinese. Eligible participants were divided into three groups based on their tertiles of SUA. Cox proportional hazards regression was used to calculate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of CRC. During a median follow-up of 13.02 years, 583 new-onset CRC cases were identified. After adjustments were made for confounders, participants in the highest tertiles of SUA exhibited a 1.55-fold increased risk of CRC compared with patients with the lowest SUA levels (HR = 1.55, 95% CI: 1.09-2.30). The associations of SUA with the risk of CRC were slightly reduced but remained substantial in the competing risk analyses when treating CRC unrelated death as the competing risk event. This study found a positive association of SUA with CRC incidence. Specific prevention efforts could be focused on the population with higher levels of SUA.
血清尿酸（SUA）可能在结直肠癌（CRC）的发生中起重要作用。本研究旨在通过从开滦研究中提取数据来探讨 SUA 与 CRC 发病风险的关系。我们前瞻性地检查了 93356 名中国人中 SUA 与 CRC 发病风险之间的关系。合格的参与者根据 SUA 的三分位将其分为三组。使用 Cox 比例风险回归计算 CRC 的风险比（HR）和 95%置信区间（95%CI）。在中位随访 13.02 年后，确定了 583 例新发生的 CRC 病例。在调整混杂因素后，与 SUA 水平最低的患者相比，SUA 水平最高的三分位患者 CRC 的风险增加了 1.55 倍（HR=1.55，95%CI：1.09-2.30）。在将与 CRC 无关的死亡作为竞争风险事件处理时，SUA 与 CRC 风险的相关性略有降低，但仍然很大。本研究发现 SUA 与 CRC 发病率呈正相关。可以将特定的预防措施集中在 SUA 水平较高的人群上。
