去极化过程中纹状体突触体中多巴胺合成的调节
Regulation of dopamine synthesis in striatal synaptosomes during depolarization.
作者信息
Kapatos G, Zigmond M J
出版信息
Brain Res. 1979 Jul 13;170(2):299-312. doi: 10.1016/0006-8993(79)90108-2.
PMID:37985
Abstract
Incubation of striatal synaptosomes under depolarizing conditions (veratridine or KCl) increased the release of dopamine (DA) and produced a small increase in DA synthesis. This was not accompanied by an activation of either soluble or membrane-bound tyrosine hydroxylase, but was associated with a large depletion of synaptosomal DA. Thus, depolarization may increase DA synthesis by reducing the inhibition of tyrosine hydroxylase by end-product.
摘要
在去极化条件下（藜芦碱或氯化钾）孵育纹状体突触体，可增加多巴胺（DA）的释放，并使DA合成略有增加。这并未伴随可溶性或膜结合型酪氨酸羟化酶的激活，但与突触体DA的大量消耗有关。因此，去极化可能通过减少终产物对酪氨酸羟化酶的抑制来增加DA合成。
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