School of Materials Science and Engineering, Key Laboratory of Advanced Civil Materials of Ministry of Education, Tongji University, Shanghai 201804, People's Republic of China.
School of Materials Science and Engineering, Key Laboratory of Advanced Civil Materials of Ministry of Education, Tongji University, Shanghai 201804, People's Republic of China.
Carbohydr Polym. 2024 Jan 15;324:121487. doi: 10.1016/j.carbpol.2023.121487. Epub 2023 Oct 11.
Traditional therapies have poor accuracy and significant toxic side effects in the process of tumor treatment. The non-traditional treatment methods with high accuracy and efficacy are worth exploring and investigating. Herein, a strategy that enables precise and synergistic therapies of calcium-overload, photodynamic, and photothermal through facile near infrared (NIR) irradiation was carried out base on the injectable and self-healable hydrogel encapsulating indocyanine green (ICG)-loaded and bovine serum albumin (BSA)-modified calcium peroxide (CaO) nanoparticles (ICG@CaO-BSA NPs) and bismuth sulfide (BiS) nanorods. The hydrogel fabricated through the dynamic Schiff-base bonds between hydroxypropyl chitosan (HPCS) and aldehyde-modified Pluronic F127 (F127-CHO) as the delivery substrate for functional substances could adhere and grip tumor tissues due to the adhesion of hydroxyl groups in HPCS and the hydrophobic aggregation caused by thermoresponsiveness of F127-CHO. CaO in ICG@CaO-BSA NPs decomposed in the tumor micro-acidic environment to produce calcium ions (Ca) and hydrogen peroxide (HO), while ICG generated reactive oxygen species (ROS) under NIR irradiation, the photothermal effect of BiS nanorods and ICG under NIR irradiation could increase the temperature of tumor tissues and ultimately achieve precise tumor cell destruction. Therefore, this strategy will provide promising prospects for precise and efficient treatment of tumors.
在肿瘤治疗过程中，传统疗法的准确性较差，且具有显著的毒副作用。具有高精度和高效能的非传统治疗方法值得探索和研究。在此，我们通过简便的近红外（NIR）照射，基于可注射和自修复的水凝胶，实现了钙超载、光动力和光热的精确协同治疗策略。该水凝胶是通过羟丙基壳聚糖（HPCS）和醛修饰的泊洛沙姆 F127（F127-CHO）之间的动态席夫碱键制备的，作为功能物质的递送载体，由于 HPCS 中的羟基的粘附性和 F127-CHO 的热响应引起的疏水性聚集，水凝胶能够粘附和抓住肿瘤组织。ICG@CaO-BSA NPs 中的 CaO 在肿瘤微酸性环境中分解生成钙离子（Ca）和过氧化氢（HO），而 ICG 在 NIR 照射下产生活性氧（ROS），BiS 纳米棒和 ICG 的光热效应在 NIR 照射下可以增加肿瘤组织的温度，最终实现精确的肿瘤细胞破坏。因此，该策略将为肿瘤的精确和高效治疗提供有前景的前景。
