Department of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, School of Materials Science and Engineering, Tongji University, Shanghai, 201804, P. R. China.
Department of Ultrasongraphy, The affiliated Zhoupu Hospital, Shanghai University of Medicine & Health Sciences, Shanghai, 201318, P. R. China.
Macromol Biosci. 2022 Sep;22(9):e2200161. doi: 10.1002/mabi.202200161. Epub 2022 Jun 28.
In order to overcome the limitation of traditional therapies for cancer and improve the accuracy of treatment, more advantageous cancer treatment methods need to be explored and studied. As a result, photothermal photodynamic therapy of breast cancer using bovine serum albumin (BSA) modifies molybdenum disulfide nanoflakes. Then the well-dispersed BSA-MoS NFs are loaded in the injectable and self-healing polysaccharide hydrogel which is prepared by the reaction of oxidized sodium alginate (OSA) and hydroxypropyl chitosan (HPCS) through the formation of Schiff base bonds. The injection and self-healing properties of the nanocomposite hydrogel are investigated. In vitro photothermal and photodynamic investigations demonstrate that BSA-MoS NFs possess obvious photothermal conversion and production of reactive oxygen species (ROS) under the irradiation of near infrared (NIR) laser (808 nm). In vivo anticancer investigation indicates that the nanocomposite hydrogel can be directly injected and remain in the tumor sites and achieve the synergistic photothermal-photodynamic therapy of cancer.
为了克服癌症传统疗法的局限性，提高治疗的准确性，需要探索和研究更有利的癌症治疗方法。因此，利用牛血清白蛋白（BSA）修饰二硫化钼纳米片，对乳腺癌进行光热光动力治疗。然后，将分散良好的 BSA-MoS NFs 负载到可注射和自修复多糖水凝胶中，该水凝胶是通过氧化的海藻酸钠（OSA）和羟丙基壳聚糖（HPCS）之间的反应，通过形成席夫碱键制备的。研究了纳米复合材料水凝胶的注射和自修复性能。体外光热和光动力研究表明，BSA-MoS NFs 在近红外（NIR）激光（808nm）照射下具有明显的光热转换和活性氧（ROS）生成能力。体内抗癌研究表明，纳米复合材料水凝胶可直接注射到肿瘤部位，并停留在肿瘤部位，实现协同光热-光动力癌症治疗。
