Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital, Kunming Medical University, Kunming, China.
Department of Anesthesiology, Kunming Medical University, Kunming, China.
Clin Respir J. 2023 Dec;17(12):1328-1340. doi: 10.1111/crj.13720. Epub 2023 Nov 20.
Dermatomyositis (DM) is often associated with interstitial lung disease (ILD) or pulmonary hypertension (PH). The aim of this study was to investigate the clinical characteristics of DM patients with ILD or PH.
This study retrospectively analysed the clinical characteristics of 372 patients with DM, including cytokines, lymphocyte subsets, immunoglobulin and complement. The DM patients were divided into different groups according to whether complicated with ILD, PH or anti-melanoma differentiation-associated gene 5 antibodies (MDA5). A qualitative and quantitative data analysis was performed.
IgG, IgA and IgM in the DM-associated ILD (ILD-DM) were higher than that of the DM non-complicating ILD (Non-ILD-DM) (p = 0.022, 0.002 and 0.029, respectively). Meanwhile, IL-6 (p = 0.008) and IL-10 (p = 0.001) were increased in the DM-associated PH (PH-DM) than in the DM non-complicating PH (Non-PH-DM), while IL-17 (p = 0.004), double positive (DP) cell ratio and B lymphocyte ratio were reduced in the PH-DM. Moreover, the incidence of ILD and levels of C4 were higher in the DM with MDA5 (MDA5 DM) than that of the DM without MDA5.
ILD-DM has higher IgG, IgA and IgM than that of Non-ILD-DM. PH-DM has higher IL-6, IL-10 and lower IL-17, DP cell ratio and B lymphocyte ratio than that of Non-PH-DM.
皮肌炎（DM）常伴有间质性肺病（ILD）或肺动脉高压（PH）。本研究旨在探讨伴发ILD 或 PH 的 DM 患者的临床特征。
本研究回顾性分析了 372 例 DM 患者的临床特征，包括细胞因子、淋巴细胞亚群、免疫球蛋白和补体。根据是否伴有 ILD、PH 或抗黑色素瘤分化相关基因 5 抗体（MDA5），将 DM 患者分为不同组。对定性和定量数据进行分析。
DM 相关性间质性肺病（ILD-DM）组 IgG、IgA 和 IgM 高于 DM 非相关性间质性肺病（Non-ILD-DM）组（p=0.022、0.002 和 0.029）。同时，DM 相关性 PH（PH-DM）组中 IL-6（p=0.008）和 IL-10（p=0.001）升高，而 PH-DM 组中 IL-17（p=0.004）、双阳性（DP）细胞比例和 B 淋巴细胞比例降低。此外，DM 伴 MDA5（MDA5 DM）患者的 ILD 发生率和 C4 水平高于无 MDA5 DM。
ILD-DM 患者的 IgG、IgA 和 IgM 高于 Non-ILD-DM。与 Non-PH-DM 相比，PH-DM 患者的 IL-6、IL-10 升高，IL-17、DP 细胞比例和 B 淋巴细胞比例降低。
