用灭活的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）BA.5单价疫苗接种可保护仓鼠免受奥密克戎毒株感染，但不能抵御非奥密克戎毒株。
Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants.
作者信息
Ong Chon Phin, Tang Kaiming, Cheung Pak-Hin Hinson, Zhang Hongzhuo, Tang Tze-Tung, Xue Yaqian, Wang Junjue, To Kelvin Kai-Wang, Yuan Shuofeng, Ye Zi-Wei, Jin Dong-Yan
机构信息
School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
出版信息
NPJ Vaccines. 2023 Nov 20;8(1):177. doi: 10.1038/s41541-023-00776-x.
We compared the protective effects of inactivated SARS-CoV-2 vaccines derived from the ancestral and the currently circulating BA.5.2 strains against infection with multiple variants in Syrian golden hamsters. Vaccination with BA.5.2 effectively protected against infection with the Omicron subvariants including XBB.1, but not the Alpha or Delta variant. In contrast, hamsters vaccinated with the ancestral strain demonstrated decent neutralization activity against both the Omicron and non-Omicron variants. Our findings might instruct future design and formulation of SARS-CoV-2 vaccines.
我们比较了源自原始毒株和当前流行的BA.5.2毒株的灭活新冠病毒疫苗对叙利亚金黄地鼠感染多种变体的保护作用。用BA.5.2疫苗接种可有效预防包括XBB.1在内的奥密克戎亚变体感染，但对阿尔法或德尔塔变体无效。相比之下，用原始毒株接种的地鼠对奥密克戎和非奥密克戎变体均表现出良好的中和活性。我们的研究结果可能为未来新冠病毒疫苗的设计和配方提供指导。
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