Fassina A S, Rugge M, Scapinello A, Viale G, Dell'Orto P, Ninfo V
Tumori. 1986 Oct 31;72(5):529-34. doi: 10.1177/030089168607200515.
A case of plasma cell granuloma (PCG) of the lung in a 54-year old man is reported. PCG is a rare benign lesion that usually presents as a solitary nodule in the lung (coin lesion) at routine X-ray examination. Microscopically it consists of a granulomatous tissue where the major components are mature plasma cells. The immunohistochemical demonstration of polyclonality of plasma cells, excluding the diagnosis of plasmacytoma, confirms the inflammatory pseudotumoral nature of this lesion, although the etiology remains obscure. The presence of lymphocytes, histiocytes, macrophages, blood vessels with prominent endothelial cells and peripheral sclero-hyalinized connective tissue may pose problems in the differential diagnosis with sclerosing hemangioma, pseudolymphoma, nodular amyloidosis, pulmonary hyalinizing granuloma, chronic abscess and neoplasms of true histiocytic origin. The term inflammatory pseudotumor is preferable in describing this type of lesion.
报告了一例54岁男性的肺浆细胞性肉芽肿（PCG）病例。PCG是一种罕见的良性病变，在常规X线检查中通常表现为肺部的孤立结节（钱币状病变）。显微镜下，它由一种肉芽肿组织组成，其主要成分是成熟的浆细胞。浆细胞多克隆性的免疫组化证实排除了浆细胞瘤的诊断，确认了该病变的炎性假瘤性质，尽管其病因仍不清楚。淋巴细胞、组织细胞、巨噬细胞、内皮细胞突出的血管以及外周硬化透明样结缔组织的存在可能在与硬化性血管瘤、假性淋巴瘤、结节性淀粉样变性、肺透明变性肉芽肿、慢性脓肿和真正组织细胞起源的肿瘤的鉴别诊断中带来问题。在描述这类病变时，炎性假瘤这一术语更为合适。
