Yapp R, Linder J, Schenken J R, Karrer F W
Hum Pathol. 1985 Aug;16(8):848-50. doi: 10.1016/s0046-8177(85)80258-6.
Plasma cell infiltrates in the thyroid are rare. They may represent several processes, such as localized plasmacytoma, multiple myeloma, or plasma cell granuloma (PCG). It may be difficult to distinguish these disorders on the basis of morphologic features in sections stained with hematoxylin-eosin. All may be composed of mature plasma cells, without admixed macrophages or lymphocytes, that infiltrate the thyroid and adjacent connective tissue. The identification of the uncommon, but benign, PCG is facilitated by immunohistochemical staining to demonstrate an admixture of plasma cells with cytoplasmic kappa and lambda light chains. The polyclonal nature of the plasma cell infiltrate distinguishes PCG from neoplastic plasma cell proliferation.
甲状腺中的浆细胞浸润很少见。它们可能代表多种病变过程，如局限性浆细胞瘤、多发性骨髓瘤或浆细胞肉芽肿（PCG）。基于苏木精-伊红染色切片的形态学特征可能难以区分这些疾病。所有这些病变可能均由成熟浆细胞组成，无混合的巨噬细胞或淋巴细胞，它们浸润甲状腺及相邻结缔组织。通过免疫组化染色显示浆细胞同时含有胞质κ和λ轻链，有助于识别这种罕见但良性的PCG。浆细胞浸润的多克隆性质可将PCG与肿瘤性浆细胞增殖区分开来。
