Hikim A P, Chakraborty J, Jhunjhunwala J S
Urology. 1987 Jan;29(1):40-4. doi: 10.1016/0090-4295(87)90595-4.
In our previous studies, we reported that short-term unilateral spermatic cord torsion had no adverse effect on the germ cells and the Sertoli cell in the contralateral testis of men. As an extension of our earlier investigations on the testicular pathophysiology in humans after unilateral spermatic cord torsion, the present study was undertaken to assess the Leydig cell function employing both fine structural and morphometric analysis in patients with short-term spermatic cord torsion. Bilateral testicular biopsy samples obtained from 4 men (15-19 years) with short-term unilateral torsion of the spermatic cord and from a control group of 6 men (15-40 years) were used in the present investigation. No appreciable difference in the Leydig morphology was noted between the biopsy samples from control and the contralateral testes. This was substantiated by morphometric analysis. The present study clearly indicates that patients with unilateral torsion of the spermatic cord may not essentially have bilateral testicular abnormalities, as suggested by the previous investigators. This report, thus lends further support to our earlier contention that alteration in microcirculation is quite likely the earliest and possibly the most significant contributor to the contralateral testicular damage in man after ipsilateral spermatic cord torsion.
在我们之前的研究中，我们报告了短期单侧精索扭转对男性对侧睾丸中的生殖细胞和支持细胞没有不良影响。作为我们早期对人类单侧精索扭转后睾丸病理生理学研究的延伸，本研究旨在通过对短期精索扭转患者进行精细结构和形态计量分析来评估睾丸间质细胞功能。本研究使用了从4名（15 - 19岁）患有短期单侧精索扭转的男性以及6名（15 - 40岁）对照组男性获取的双侧睾丸活检样本。在对照组和对侧睾丸的活检样本之间，未观察到睾丸间质细胞形态有明显差异。这一点通过形态计量分析得到了证实。本研究清楚地表明，如先前研究者所暗示的那样，单侧精索扭转患者不一定存在双侧睾丸异常。因此，本报告进一步支持了我们之前的观点，即微循环改变很可能是同侧精索扭转后男性对侧睾丸损伤最早且可能是最主要的因素。
