Karagüzel G, Gedikoğlu G, Tanyel F C, Büyükpamukçu N, Hiçsönmez A
Department of Pediatric Surgery, Hacettepe University, School of Medicine, Cocuk Cerrahisi Anabilim Dali, Ankara, Turkey.
Urol Res. 1994;22(2):115-7. doi: 10.1007/BF00311002.
Although deteriorating effects of unilateral spermatic cord torsion are generally accepted, the mechanism remains controversial. An experimental study was performed to evaluate the necessity of testicular and spermatogenetic material for contralateral testicular deterioration following unilateral spermatic cord torsion in rats. The animals were allocated to four groups: control, spermatic cord torsion, subepididymal orchiectomy, and spermatic cord torsion 14 days after subepididymal orchiectomy. The testes were removed on the 14th days and mean seminiferous tubular diameters and mean testicular biopsy scores were determined. Although contralateral testicular deterioration was more pronounced in the presence of testicular tissue, the absence of testicular tissue and/or spermatogenetic material did not prevent its occurrence. This is highly suggestive that autoimmune mechanism does not play a role in contralateral testicular damage following unilateral spermatic cord torsion.
尽管单侧精索扭转的恶化效应已被普遍认可，但其机制仍存在争议。进行了一项实验研究，以评估大鼠单侧精索扭转后对侧睾丸恶化时睾丸及生精物质的必要性。将动物分为四组：对照组、精索扭转组、附睾下睾丸切除术组以及附睾下睾丸切除术后14天进行精索扭转组。在第14天取出睾丸，测定生精小管平均直径和平均睾丸活检评分。尽管存在睾丸组织时对侧睾丸恶化更为明显，但睾丸组织和/或生精物质的缺失并未阻止其发生。这强烈表明自身免疫机制在单侧精索扭转后对侧睾丸损伤中不起作用。
