Shandong University of Traditional Chinese Medicine, Jinan, People's Republic of China.
Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, People's Republic of China.
Medicine (Baltimore). 2023 Nov 17;102(46):e36157. doi: 10.1097/MD.0000000000036157.
Gastric cancer (GC) is a global public health concern that poses a serious threat to human health owing to its high morbidity and mortality rates. Due to the lack of specificity of symptoms, patients with GC tend to be diagnosed at an advanced stage with poor prognosis. Therefore, the development of new treatment methods is particularly urgent. Chronic atrophic gastritis (CAG), a precancerous GC lesion, plays a key role in its occurrence and development. Oxidative stress has been identified as an important factor driving the development and progression of the pathological processes of CAG and GC. Therefore, regulating oxidative stress pathways can not only intervene in CAG development but also prevent the occurrence and metastasis of GC and improve the prognosis of GC patients. In this study, PubMed, CNKI, and Web of Science were used to search for a large number of relevant studies. The review results suggested that the active ingredients of traditional Chinese medicine (TCM) and TCM prescriptions could target and improve inflammation, pathological status, metastasis, and invasion of tumor cells, providing a potential new supplement for the treatment of CAG and GC.
胃癌（GC）是一个全球性的公共卫生关注点，由于其高发病率和死亡率，对人类健康构成严重威胁。由于症状缺乏特异性，GC 患者往往在晚期被诊断出，预后较差。因此，开发新的治疗方法尤为紧迫。慢性萎缩性胃炎（CAG）作为一种癌前 GC 病变，在其发生和发展中起着关键作用。氧化应激已被确定为驱动 CAG 和 GC 病理过程发展和进展的重要因素。因此，调节氧化应激途径不仅可以干预 CAG 的发展，还可以预防 GC 的发生和转移，并改善 GC 患者的预后。在本研究中，我们使用 PubMed、CNKI 和 Web of Science 搜索了大量相关研究。综述结果表明，中药（TCM）的活性成分和 TCM 方剂可以针对并改善炎症、病理状态、转移和肿瘤细胞的侵袭，为 CAG 和 GC 的治疗提供了一种潜在的新补充。
