Erickson Melissa L, Blackwell Terri L, Mau Theresa, Cawthon Peggy M, Glynn Nancy W, Qiao Yujia Susanna, Cummings Steven R, Coen Paul M, Lane Nancy E, Kritchevsky Stephen B, Newman Anne B, Farsijani Samaneh, Esser Karyn A
Translational Research Institute, AdventHealth, Orlando, FL.
San Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.
medRxiv. 2023 Nov 12:2023.11.11.23298422. doi: 10.1101/2023.11.11.23298422.
Aging is associated with declines in circadian functions. The effects of aging on circadian patterns of behavior are insufficiently described. We characterized age-specific features of rest-activity rhythms (RAR) in community dwelling older adults, both overall, and in relation, to sociodemographic characteristics.
We analyzed baseline assessments of older adults with wrist-worn free-living wrist-worn actigraphy data (N=820, Age=76.4 yrs, 58.2% women) participating in the Study of Muscle, Mobility and Aging (SOMMA). We applied an extension to the traditional cosine curve to map RAR to activity data, calculating the parameters: rhythmic strength (amplitude); robustness (pseudo-F statistic); and timing of peak activity (acrophase). We also used function principal component analysis to determine 4 components describing underlying patterns of activity accounting for RAR variance. Linear models were used to examine associations between RAR and sociodemographic variables.
Age was associated with several metrics of dampened RAR; women had stronger and more robust RAR metrics vs. men (all < 0.05). Total activity (56%) and time of activity (20%) accounted for most the RAR variance. Compared to the latest decile of acrophase, those in the earliest decile had higher average amplitude ( <0.001). Compared to the latest decile of acrophase, those is the earliest and midrange categories had more total activity (=0.02). RAR was associated with some sociodemographic variables.
Older age was associated with dampened circadian behavior; and behaviors were sexually dimorphic. We identified a behavioral phenotype characterized by early time-of-day of peak activity, high rhythmic amplitude, and more total activity.
衰老与昼夜节律功能下降有关。衰老对行为昼夜节律模式的影响描述不足。我们描述了社区居住的老年人休息-活动节律（RAR）的年龄特异性特征，包括总体特征以及与社会人口学特征的关系。
我们分析了参与肌肉、 Mobility和衰老研究（SOMMA）的老年人的基线评估数据，这些数据来自佩戴在手腕上的自由生活活动记录仪（N = 820，年龄 = 76.4岁，女性占58.2%）。我们对传统余弦曲线进行了扩展，以将RAR映射到活动数据，计算参数：节律强度（振幅）；稳健性（伪F统计量）；以及活动峰值时间（相位角）。我们还使用功能主成分分析来确定描述活动潜在模式的4个成分，这些成分解释了RAR的方差。线性模型用于检验RAR与社会人口学变量之间的关联。
年龄与RAR减弱的几个指标相关；女性的RAR指标比男性更强且更稳健（均P < 0.05）。总活动量（56%）和活动时间（20%）占RAR方差的大部分。与相位角最晚的十分位数相比，最早的十分位数的平均振幅更高（P < 0.001）。与相位角最晚的十分位数相比，最早和中间范围类别的总活动量更多（P = 0.02）。RAR与一些社会人口学变量相关。
老年与昼夜节律行为减弱有关；并且行为存在性别差异。我们确定了一种行为表型，其特征为活动峰值出现时间早、节律振幅高以及总活动量更多。
