Weng Geyu, Akbarian Amir, Clark Kelsey, Noudoost Behrad, Nategh Neda
Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA.
Department of Ophthalmology and V7isual Sciences, University of Utah, Salt Lake City, UT, USA.
bioRxiv. 2023 Nov 7:2023.11.06.565871. doi: 10.1101/2023.11.06.565871.
When interacting with the visual world using saccadic eye movements (saccades), the perceived location of visual stimuli becomes biased, a phenomenon called perisaccadic mislocalization, which is indeed an exemplar of the brain's dynamic representation of the visual world. However, the neural mechanism underlying this altered visuospatial perception and its potential link to other perisaccadic perceptual phenomena have not been established. Using a combined experimental and computational approach, we were able to quantify spatial bias around the saccade target (ST) based on the perisaccadic dynamics of extrastriate spatiotemporal sensitivity captured by statistical models. This approach could predict the perisaccadic spatial bias around the ST, consistent with the psychophysical studies, and revealed the precise neuronal response components underlying representational bias. These findings also established the crucial role of response remapping toward ST representation for neurons with receptive fields far from the ST in driving the ST spatial bias. Moreover, we showed that, by allocating more resources for visual target representation, visual areas enhance their representation of the ST location, even at the expense of transient distortions in spatial representation. This potential neural basis for perisaccadic ST representation, also supports a general role for extrastriate neurons in creating the perception of stimulus location.
当使用扫视眼动（扫视）与视觉世界进行交互时，视觉刺激的感知位置会出现偏差，这种现象称为扫视周边位置错误定位，它实际上是大脑对视觉世界动态表征的一个典型例子。然而，这种视觉空间感知改变背后的神经机制及其与其他扫视周边感知现象的潜在联系尚未确定。我们采用实验与计算相结合的方法，基于统计模型捕获的纹外时空敏感性的扫视周边动态，能够量化扫视目标（ST）周围的空间偏差。这种方法可以预测ST周围的扫视周边空间偏差，与心理物理学研究结果一致，并揭示了表征偏差背后精确的神经元反应成分。这些发现还确立了对于感受野远离ST的神经元，其向ST表征的反应重映射在驱动ST空间偏差方面的关键作用。此外，我们表明，通过为视觉目标表征分配更多资源，视觉区域增强了它们对ST位置的表征，即使是以空间表征的短暂扭曲为代价。这种扫视周边ST表征的潜在神经基础，也支持了纹外神经元在产生刺激位置感知方面的一般作用。
