Bring Horvath Elijah R, Brazelton William J, Kim Min Cheol, Cullum Reiko, Mulvey Matthew A, Fenical William, Winter Jaclyn M
Department of Pharmacology and Toxicology, Department of Medicinal Chemistry, University of Utah, Salt Lake City, United States.
School of Biological Sciences, University of Utah, Salt Lake City, United States.
bioRxiv. 2023 Nov 8:2023.11.07.565188. doi: 10.1101/2023.11.07.565188.
Great Salt Lake (GSL), located northwest of Salt Lake City, UT, is the largest terminal lake in the United States. While the average salinity of seawater is ~3.3%, the salinity in GSL ranges between 5-28%. In addition to being a hypersaline environment, GSL also contains toxic concentrations of heavy metals, such as arsenic, mercury, and lead. The extreme environment of GSL makes it an intriguing subject of study, both for its unique microbiome and its potential to harbor novel natural product-producing bacteria, which could be used as resources for the discovery of biologically active compounds. Though work has been done to survey and catalogue bacteria found in GSL, the Lake's microbiome is largely unexplored, and little-to-no work has been done to characterize the natural product potential of GSL microbes. Here, we investigate the bacterial diversity of two important regions within GSL, describe the first genomic characterization of Actinomycetota isolated from GSL sediment, including the identification of a new species, and provide the first survey of the natural product potential of GSL bacteria.
大盐湖（GSL）位于犹他州盐湖城的西北部，是美国最大的终点湖。虽然海水的平均盐度约为3.3%，但大盐湖的盐度在5%至28%之间。除了是一个高盐环境外，大盐湖还含有有毒浓度的重金属，如砷、汞和铅。大盐湖的极端环境使其成为一个有趣的研究对象，这既是因为其独特的微生物群落，也是因为它有潜力蕴藏能产生新型天然产物的细菌，这些细菌可作为发现生物活性化合物的资源。尽管已经开展了工作来调查和编目大盐湖中发现的细菌，但该湖的微生物群落基本上仍未得到充分探索，而且几乎没有开展工作来表征大盐湖微生物产生天然产物的潜力。在这里，我们调查了大盐湖内两个重要区域的细菌多样性，描述了从大盐湖沉积物中分离出的放线菌门的首次基因组特征，包括鉴定一个新物种，并首次对大盐湖细菌产生天然产物的潜力进行了调查。
