红细胞沉降率（ESR）在骨髓增殖性疾病和淋巴细胞增殖性疾病中的作用：迪赛CUBE 30 TOUCH与阿利法克斯Test 1的比较

The Role of Erythrocyte Sedimentation Rate (ESR) in Myeloproliferative and Lymphoproliferative Diseases: Comparison between DIESSE CUBE 30 TOUCH and Alifax Test 1.

作者信息

Pelagalli Martina, Tomassetti Flaminia, Nicolai Eleonora, Giovannelli Alfredo, Codella Silvia, Iozzo Mariannina, Massoud Renato, Secchi Roberto, Venditti Adriano, Pieri Massimo, Bernardini Sergio

机构信息

Department of Experimental Medicine, University of Rome "Tor Vergata", Via Montpellier 1, 00133 Rome, Italy.

Department of Laboratory Medicine, "Tor Vergata" University Hospital, Viale Oxford 81, 00133 Rome, Italy.

出版信息

Diseases. 2023 Nov 15;11(4):169. doi: 10.3390/diseases11040169.

DOI:10.3390/diseases11040169

PMID:37987280

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10660727/

Abstract

(1) Background: The erythrocyte sedimentation rate (ESR) is widely diffused in hematology laboratories to monitor inflammatory statuses, response to therapies (such as antibiotics), and oncologic diseases. However, ESR is not a specific diagnostic marker but needs to be contextualized and compared with clinical and other laboratory findings. This study aimed to investigate the performance of two automated instruments, namely the DIESSE CUBE 30 TOUCH (DIESSE, Siena, Italy) and the Alifax Test 1 (Alifax Srl, Polverara, Italy), in comparison with the gold standard, the Westergren method, in lymphoproliferative and myeloproliferative patients. (2) Methods: 97 EDTA samples were selected from the hematology department of Roma Tor Vergata Hospital and analyzed. Statistical analysis was applied. (3) A good correlation between CUBE 30 TOUCH and the gold standard was observed in the overall sample (R = 0.90), as well as in patients with lymphoproliferative diseases (R = 0.90) and myeloproliferative diseases (R = 0.90). The correlation between Test 1 and the gold standard was observed in the overall sample (R = 0.68), as well as in patients with lymphoproliferative diseases (R = 0.79) and myeloproliferative diseases (R = 0.53). (4) Conclusions: The CUBE 30 TOUCH appears to be a more trustworthy tool for evaluating ESR in these pathologies.

摘要

(1) 背景：红细胞沉降率（ESR）在血液学实验室中广泛用于监测炎症状态、对治疗（如抗生素）的反应以及肿瘤疾病。然而，ESR并非特异性诊断标志物，需要结合临床及其他实验室检查结果进行综合判断。本研究旨在比较两种自动化仪器，即DIESSE CUBE 30 TOUCH（意大利锡耶纳的DIESSE公司）和Alifax Test 1（意大利波尔韦拉的Alifax Srl公司）与金标准韦斯特格伦法在淋巴增殖性和骨髓增殖性疾病患者中的表现。(2) 方法：从罗马第二大学医院血液科选取97份EDTA样本进行分析，并应用统计学分析。(3) 在总体样本（R = 0.90）、淋巴增殖性疾病患者（R = 0.90）和骨髓增殖性疾病患者（R = 0.90）中，均观察到CUBE 30 TOUCH与金标准之间具有良好的相关性。在总体样本（R = 0.68）、淋巴增殖性疾病患者（R = 0.79）和骨髓增殖性疾病患者（R = 0.53）中，观察到Test 1与金标准之间的相关性。(4) 结论：对于这些疾病，CUBE 30 TOUCH似乎是评估ESR更可靠的工具。