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原发性眼眶黏液样脂肪肉瘤。

Primary Orbital Myxoid Liposarcoma.

机构信息

Laboratory of Pathology and Cytopathology "Dr. Miguel Benavides", Morelia 58260, Michoacán, Mexico.

High Specialty Visual Clinic, Acámbaro 38600, Guanajuato, Mexico.

出版信息

Med Sci (Basel). 2023 Nov 8;11(4):72. doi: 10.3390/medsci11040072.

DOI:10.3390/medsci11040072
PMID:37987327
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10660850/
Abstract

Although liposarcoma is the most prevalent soft tissue sarcoma in adults, head and neck liposarcomas are rare and account for less than 5% of all liposarcomas. The primary orbital location is even more exceptional, with fewer than 100 cases documented in the medical literature. Given the scarcity of cases of orbital liposarcoma and the limited familiarity of physicians and pathologists with this pathology, there is an increased risk of non-diagnosis or misdiagnosis, which may lead to inappropriate patient management. To address these challenges, we present a case of primary orbital myxoid liposarcoma and subsequently discuss the primary findings of this case based on the evidence documented in the medical literature. This comprehensive text is designed to serve as a valuable resource for healthcare professionals and pathologists, with the goal of promoting both clinical suspicion and accurate diagnosis and treatment of this rare condition in future cases.

摘要

虽然脂肪肉瘤是成年人中最常见的软组织肉瘤,但发生在头颈部的脂肪肉瘤却很少见,不到所有脂肪肉瘤的 5%。原发于眶内的位置更为特殊,在医学文献中记录的病例不足 100 例。鉴于眶内脂肪肉瘤病例稀少,且医生和病理学家对这种病理的了解有限,因此存在诊断不明确或误诊的风险,这可能导致患者的治疗不当。为了解决这些挑战,我们提出了一个原发于眶内的黏液样脂肪肉瘤的病例,并根据文献中的证据讨论了这个病例的主要发现。这份全面的文本旨在为医疗保健专业人员和病理学家提供有价值的资源,目标是在未来的病例中提高对这种罕见疾病的临床怀疑和准确诊断及治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f314/10660850/f8aa4594a9af/medsci-11-00072-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f314/10660850/3ed978f68e0a/medsci-11-00072-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f314/10660850/f8aa4594a9af/medsci-11-00072-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f314/10660850/3ed978f68e0a/medsci-11-00072-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f314/10660850/f8aa4594a9af/medsci-11-00072-g002.jpg

相似文献

1
Primary Orbital Myxoid Liposarcoma.原发性眼眶黏液样脂肪肉瘤。
Med Sci (Basel). 2023 Nov 8;11(4):72. doi: 10.3390/medsci11040072.
2
A rare case of primary giant myxoid liposarcoma of the pericardium.一例罕见的原发性心包巨大黏液样脂肪肉瘤。
Indian J Pathol Microbiol. 2023 Apr-Jun;66(2):347-349. doi: 10.4103/ijpm.ijpm_545_21.
3
Myxoid liposarcoma of the ankle.踝关节黏液样脂肪肉瘤
J Foot Ankle Surg. 1995 Sep-Oct;34(5):465-74. doi: 10.1016/S1067-2516(09)80022-7.
4
Myxoid liposarcoma of the retropatellar fat pad.髌下脂肪垫黏液样脂肪肉瘤
Am J Orthop (Belle Mead NJ). 1997 Apr;26(4):287-9.
5
Liposarcoma of the extremities: MR imaging features and their correlation with pathologic data.四肢脂肪肉瘤:MR 成像特征及其与病理数据的相关性。
Orthop Traumatol Surg Res. 2010 Dec;96(8):876-83. doi: 10.1016/j.otsr.2010.05.010. Epub 2010 Oct 12.
6
[Orbital metastasis of liposarcoma].[脂肪肉瘤的眼眶转移]
J Fr Ophtalmol. 2007 Nov;30(9):e28. doi: 10.1016/s0181-5512(07)74036-6.
7
Myxoid liposarcoma of the ankle: a case report.踝关节黏液样脂肪肉瘤:一例报告
J Foot Ankle Surg. 2012 Jan-Feb;51(1):76-9. doi: 10.1053/j.jfas.2011.09.005. Epub 2011 Oct 21.
8
Myxoid liposarcoma in a 12-year-old girl.一名12岁女孩的黏液样脂肪肉瘤。
Pediatr Dermatol. 2000 Mar-Apr;17(2):129-32. doi: 10.1046/j.1525-1470.2000.01731.x.
9
[Myxoid liposarcoma. MRI imaging].[黏液样脂肪肉瘤。磁共振成像]
J Radiol. 1995 Jan;76(1):29-36.
10
Myxoid liposarcoma: appearance at MR imaging with histologic correlation.黏液样脂肪肉瘤:磁共振成像表现与组织学对照
Radiographics. 2000 Jul-Aug;20(4):1007-19. doi: 10.1148/radiographics.20.4.g00jl021007.

本文引用的文献

1
Orbital Liposarcoma: A Surveillance, Epidemiology and End Results Database Study.眼眶脂肪肉瘤:监测、流行病学和最终结果数据库研究。
Ophthalmic Plast Reconstr Surg. 2024;40(1):93-98. doi: 10.1097/IOP.0000000000002516. Epub 2023 Sep 11.
2
Orbital liposarcoma: a retrospective, single-center study of thirteen patients.眼眶脂肪肉瘤:一项针对13例患者的回顾性单中心研究。
Int J Ophthalmol. 2023 Aug 18;16(8):1293-1298. doi: 10.18240/ijo.2023.08.16. eCollection 2023.
3
Immunotherapy for liposarcoma: emerging opportunities and challenges.
脂肪肉瘤的免疫治疗:新出现的机遇与挑战。
Future Oncol. 2022 Sep;18(30):3449-3461. doi: 10.2217/fon-2021-1549. Epub 2022 Oct 10.
4
Fusion protein-driven IGF-IR/PI3K/AKT signals deregulate Hippo pathway promoting oncogenic cooperation of YAP1 and FUS-DDIT3 in myxoid liposarcoma.融合蛋白驱动的IGF-IR/PI3K/AKT信号失调Hippo通路,促进黏液样脂肪肉瘤中YAP1和FUS-DDIT3的致癌协同作用。
Oncogenesis. 2022 Apr 22;11(1):20. doi: 10.1038/s41389-022-00394-7.
5
FUS-DDIT3 Fusion Oncoprotein Expression Affects JAK-STAT Signaling in Myxoid Liposarcoma.FUS-DDIT3融合癌蛋白表达影响黏液样脂肪肉瘤中的JAK-STAT信号通路。
Front Oncol. 2022 Feb 3;12:816894. doi: 10.3389/fonc.2022.816894. eCollection 2022.
6
Primary dedifferentiated liposarcoma of the orbit, a rare entity: Case report and review of literature.眼眶原发性去分化脂肪肉瘤,一种罕见的疾病:病例报告及文献复习
Saudi J Ophthalmol. 2019 Jul-Sep;33(3):312-315. doi: 10.1016/j.sjopt.2019.01.003. Epub 2019 Jan 16.
7
Carunclar Mass as the Presenting Sign of Primary Orbital Liposarcoma.泪阜肿物作为原发性眼眶脂肪肉瘤的首发体征
Middle East Afr J Ophthalmol. 2019 Sep 30;26(3):172-174. doi: 10.4103/meajo.MEAJO_69_18. eCollection 2019 Jul-Sep.
8
Clinical and Molecular Spectrum of Liposarcoma.脂肪肉瘤的临床与分子谱。
J Clin Oncol. 2018 Jan 10;36(2):151-159. doi: 10.1200/JCO.2017.74.9598. Epub 2017 Dec 8.
9
Detection of myxoid liposarcoma-associated FUS-DDIT3 rearrangement variants including a newly identified breakpoint using an optimized RT-PCR assay.采用优化的 RT-PCR 检测方法检测黏液样脂肪肉瘤相关的 FUS-DDIT3 重排变体,包括新发现的断点。
Mod Pathol. 2010 Oct;23(10):1307-15. doi: 10.1038/modpathol.2010.118. Epub 2010 Jun 25.
10
Primary orbital liposarcoma.原发性眼眶脂肪肉瘤。
Ophthalmology. 2010 Mar;117(3):606-14. doi: 10.1016/j.ophtha.2009.08.017. Epub 2009 Dec 22.