Yang Shangru, Zeng Haohao, Luo Meiming, Zeng Xiaoming
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China.
Org Biomol Chem. 2023 Dec 6;21(47):9337-9340. doi: 10.1039/d3ob01728a.
Reported here is the reductive transamidation of tertiary amides with nitroarenes promoted by main group metal magnesium and chlorosilane. The reaction uses commercially available and air-stable nitroarenes as nitrogen sources, so it can occur under transition-metal- and ligand-free conditions, thus providing a step-economic and cost-effective strategy for forming centrally important secondary amides. Several biologically interesting amide motifs are readily accessible by the Mg-promoted reductive transamidation.
本文报道了主族金属镁和氯硅烷促进的叔酰胺与硝基芳烃的还原转酰胺反应。该反应使用市售且对空气稳定的硝基芳烃作为氮源，因此可以在无过渡金属和无配体的条件下进行，从而为形成至关重要的仲酰胺提供了一种步骤经济且成本效益高的策略。通过镁促进的还原转酰胺反应可以很容易地获得几种具有生物学意义的酰胺基序。
