铬催化下镁对酰基碳-氧键的活化用于酯与硝基芳烃的酰胺化反应
Chromium-Catalyzed Activation of Acyl C-O Bonds with Magnesium for Amidation of Esters with Nitroarenes.
作者信息
Ling Liang, Chen Changpeng, Luo Meiming, Zeng Xiaoming
机构信息
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry , Sichuan University , Chengdu 610064 , China.
Frontier Institute of Science and Technology , Xi'an Jiaotong University , Xi'an 710054 , China.
出版信息
Org Lett. 2019 Mar 15;21(6):1912-1916. doi: 10.1021/acs.orglett.9b00554. Epub 2019 Mar 5.
Here, we report a chromium-catalyzed activation of acyl C-O bonds with magnesium for amidation of esters with nitroarenes. Low-cost chromium(III) chloride shows high reactivity in promoting amidation by using magnesium as reductant and chlorotrimethylsilane as additive. It provides a step-economic strategy to the synthesis of centrally important amide motifs using inexpensive and air-stable nitroarenes as amino sources.
在此，我们报道了一种铬催化的酰基C-O键与镁的活化反应，用于酯与硝基芳烃的酰胺化反应。低成本的三氯化铬在以镁作为还原剂和氯代三甲基硅烷作为添加剂促进酰胺化反应中表现出高反应活性。它为使用廉价且对空气稳定的硝基芳烃作为氨基源合成核心重要的酰胺基序提供了一种步骤经济的策略。
Zotero 插件