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Little to no mRNA for the α- or β-chains of FcεRI in human eosinophils.

作者信息

Chhiba Krishan D, Kuang Fei Li, Berdnikovs Sergejs, Kato Atsushi, Bochner Bruce S

机构信息

Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill.

Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill.

出版信息

J Allergy Clin Immunol. 2024 Feb;153(2):533-534. doi: 10.1016/j.jaci.2023.10.014. Epub 2023 Nov 21.

DOI:10.1016/j.jaci.2023.10.014
PMID:37988049
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10922093/
Abstract
摘要

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Increased expression of high affinity IgE (FcepsilonRI) receptor-alpha chain mRNA and protein-bearing eosinophils in human allergen-induced atopic asthma.在人类变应原诱导的特应性哮喘中,高亲和力IgE(FcepsilonRI)受体α链mRNA及含该蛋白的嗜酸性粒细胞表达增加。
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Anti-IgE therapy in chronic rhinosinusitis with nasal polyps.抗IgE疗法用于伴鼻息肉的慢性鼻-鼻窦炎
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本文引用的文献

1
Circulating Human Eosinophils Share a Similar Transcriptional Profile in Asthma and Other Hypereosinophilic Disorders.循环中的人类嗜酸性粒细胞在哮喘和其他嗜酸性粒细胞增多症中具有相似的转录谱。
PLoS One. 2015 Nov 2;10(11):e0141740. doi: 10.1371/journal.pone.0141740. eCollection 2015.
2
Blood eosinophils from atopic donors express messenger RNA for the alpha, beta, and gamma subunits of the high-affinity IgE receptor (Fc epsilon RI) and intracellular, but not cell surface, alpha subunit protein.来自特应性供体的血液嗜酸性粒细胞表达高亲和力IgE受体(FcεRI)α、β和γ亚基的信使核糖核酸以及细胞内α亚基蛋白,但不表达细胞表面α亚基蛋白。
J Allergy Clin Immunol. 2000 Feb;105(2 Pt 1):309-17. doi: 10.1016/s0091-6749(00)90081-2.
3
Does IgE bind to and activate eosinophils from patients with allergy?免疫球蛋白E(IgE)是否会结合并激活过敏患者的嗜酸性粒细胞?
J Immunol. 1999 Jun 1;162(11):6901-11.
4
Intracellular expression and release of Fc epsilon RI alpha by human eosinophils.人嗜酸性粒细胞中FcεRIα的细胞内表达与释放
J Immunol. 1999 Jun 1;162(11):6893-900.
5
Eosinophils and IgE receptors: a continuing controversy.嗜酸性粒细胞与IgE受体:持续的争议
Blood. 1997 May 15;89(10):3497-501.