患者对鸡蛋过敏后获得耐受，食用鹌鹑蛋的临床特征：病例系列研究。
Clinical Features of Quail Egg Ingestion in Patients with Acquired Tolerance to Hen Eggs: A Case Series Study.
机构信息
Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan.
出版信息
Int Arch Allergy Immunol. 2024;185(2):152-157. doi: 10.1159/000534825. Epub 2023 Nov 21.
INTRODUCTION
Patients with hen's egg allergy are often instructed to avoid consuming other avian eggs, such as quail eggs. However, it is unclear whether patients with an acquired tolerance to hen eggs continue to avoid consuming quail eggs. This study aimed to evaluate the clinical features of quail egg ingestion.
METHODS
This prospective case series included children aged ≥1 year with hen's egg allergy who were recruited between October 2019 and February 2021 in our hospital. We conducted an oral food challenge (OFC) with three boiled quail eggs to evaluate the clinical features of quail egg ingestion in patients with acquired tolerance to hen eggs. The primary outcome was a positive OFC after ingesting three quail eggs. Secondary outcomes were cross-antigenicity between hen and quail eggs observed through the skin prick test (SPT) and pattern of quail egg allergy, comprising the onset of reaction, and severity. The correlation between the diameters of the wheals with SPT in hen and quail eggs was evaluated using the Pearson product-moment correlation coefficient.
RESULTS
A total of 62 patients underwent the quail egg OFC. The median (interquartile range) age of the participants was 3 (2-5) years. Thirty-three (53%) patients had a history of anaphylaxis due to hen eggs. The median total immunoglobulin E (IgE) level in patients who underwent the OFC with half a heated whole hen's egg was 271 (98-593) IU/mL. The median specific IgE level in egg white and ovomucoid was 9.7 (3.2-21.5) and 4.4 (1.3-6.9) UA/mL, respectively. The quail egg OFC results revealed that none of the 59 patients who ate the three quail eggs completely had an allergic reaction. The SPT-positive and SPT-negative rates in raw and boiled hen and quail egg whites were both correlated. The diameters of wheals with SPT in raw hen and quail egg whites and yolks were positively correlated.
CONCLUSION
Patients with an acquired tolerance to hen eggs may not be required to avoid consuming quail eggs.
简介
对鸡蛋过敏的患者通常被要求避免食用其他禽类的蛋，如鹌鹑蛋。然而，对于获得鸡蛋耐受的患者是否继续避免食用鹌鹑蛋，目前尚不清楚。本研究旨在评估鹌鹑蛋摄入的临床特征。
方法
本前瞻性病例系列研究纳入了 2019 年 10 月至 2021 年 2 月期间在我院就诊的年龄≥1 岁且对鸡蛋过敏的儿童。我们对其进行了 3 个煮鹌鹑蛋的口服食物激发试验（OFC），以评估获得鸡蛋耐受的患者摄入鹌鹑蛋的临床特征。主要结局是摄入 3 个鹌鹑蛋后 OFC 阳性。次要结局是皮肤点刺试验（SPT）观察到的鸡蛋和鹌鹑蛋之间的交叉抗原性，以及鹌鹑蛋过敏的模式，包括反应的发作和严重程度。通过皮尔逊积矩相关系数评估 SPT 中鸡蛋和鹌鹑蛋风团直径之间的相关性。
结果
共有 62 名患者接受了鹌鹑蛋 OFC。参与者的中位（四分位间距）年龄为 3（2-5）岁。33 名（53%）患者有因鸡蛋而发生过敏反应的病史。接受半加热全鸡蛋 OFC 的患者的总免疫球蛋白 E（IgE）水平中位数为 271（98-593）IU/ml。鸡蛋白和卵类黏蛋白的特异性 IgE 水平中位数分别为 9.7（3.2-21.5）和 4.4（1.3-6.9）UA/ml。鹌鹑蛋 OFC 结果显示，完全食用 3 个鹌鹑蛋的 59 名患者均无过敏反应。生的和煮的鸡蛋和鹌鹑蛋蛋清的 SPT 阳性率和 SPT 阴性率均相关。生的和煮的鸡蛋和鹌鹑蛋蛋清和蛋黄 SPT 风团直径呈正相关。
结论
获得鸡蛋耐受的患者可能无需避免食用鹌鹑蛋。
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