Department of Cardiovascular Medicine, Heart, Vascular & Thoracic Institute, Cleveland Clinic, Cleveland, Ohio, USA; email:
Annu Rev Med. 2024 Jan 29;75:475-492. doi: 10.1146/annurev-med-051022-042616. Epub 2023 Nov 21.
Cardiac pacing to treat bradyarrhythmias has evolved in recent decades. Recognition that a substantial proportion of pacemaker-dependent patients can develop heart failure due to electrical and mechanical dyssynchrony from traditional right ventricular apical pacing has led to development of more physiologic pacing methods that better mimic normal cardiac conduction and provide synchronized ventricular contraction. Conventional biventricular pacing has been shown to benefit patients with heart failure and conduction system disease but can be limited by scarring and fibrosis. His bundle pacing and left bundle branch area pacing are novel techniques that can provide more physiologic ventricular activation as an alternative to conventional or biventricular pacing. Leadless pacing has emerged as another alternative pacing technique to overcome limitations in conventional transvenous pacemaker systems. Our objective is to review the evolution of cardiac pacing and explore these new advances in pacing strategies.
近年来,心脏起搏治疗缓律失常的方法不断发展。由于传统的右心室心尖部起搏会导致电和机械不同步,从而导致相当一部分依赖起搏器的患者发生心力衰竭,因此开发了更符合生理的起搏方法,这些方法可以更好地模拟正常心脏传导并提供同步的心室收缩。传统的双心室起搏已被证明对心力衰竭和传导系统疾病的患者有益,但可能受到瘢痕和纤维化的限制。希氏束起搏和左束支区域起搏是新的技术,可作为传统或双心室起搏的替代方法,提供更符合生理的心室激活。无导线起搏已成为克服传统经静脉起搏器系统局限性的另一种替代起搏技术。我们的目的是回顾心脏起搏的发展,并探讨起搏策略的这些新进展。