破骨细胞中膜微域的结构与功能。

Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Department of Orthopaedics, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Bone Res. 2023 Nov 21;11(1):61. doi: 10.1038/s41413-023-00294-5.

The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed in the clinic and is an important target to the development of therapeutic strategies for these diseases. Strong experimental evidence supports the existence of membrane microdomains in osteoclasts (OCs). However, the potential membrane microdomains and the crucial mechanisms underlying their roles in OCs have not been fully characterized. Membrane microdomain components, such as scaffolding proteins and the actin cytoskeleton, as well as the roles of individual membrane proteins, need to be elucidated. In this review, we discuss the compositions and critical functions of membrane microdomains that determine the biological behavior of OCs through the three main stages of the OC life cycle.

细胞膜结构与临床上观察到的许多代谢性骨疾病的发生和进展密切相关，是开发这些疾病治疗策略的重要靶点。强有力的实验证据支持破骨细胞（OCs）中存在膜微区。然而，OCs 中膜微区的潜在组成及其关键机制尚未得到充分描述。膜微区成分，如支架蛋白和肌动蛋白细胞骨架，以及单个膜蛋白的作用，都需要阐明。在这篇综述中，我们通过 OC 生命周期的三个主要阶段讨论了决定 OC 生物学行为的膜微区的组成和关键功能。