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经胸心外膜起搏器治疗婴幼儿先天性完全性房室传导阻滞的经验:一项回顾性研究。

Experience of treating congenital complete atrioventricular block with epicardial pacemaker in infants and young children: a retrospective study.

机构信息

Department of Pediatric Cardiology, Faculty of Pediatrics, The Seventh Medical Center of Chinese PLA General Hospital, NO. 5 Nanmencang, Dongcheng District, Beijing, 100700, China.

Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.

出版信息

BMC Cardiovasc Disord. 2023 Nov 21;23(1):575. doi: 10.1186/s12872-023-03620-1.

Abstract

BACKGROUND

This article summarizes the treatment experience for congenital complete atrioventricular block (CCAVB) in newborns and infants, and discusses the necessity and feasibility of treating CCAVB with permanent pacemaker implantation in this population.

METHODS

In this study, the clinical data and follow-up results of nine children admitted at our center with CCAVB from January 2005 to March 2023 were retrospectively analyzed. Among them, two children received early implantation of permanent pacemakers (within 1 year of age), two children received non-early implantation (1 year or older), and the remaining five children received no pacemaker implantation. CCAVB diagnosis was confirmed by clinical symptoms and clinical examinations, including electrocardiography and echocardiography before surgery. After surgery, the pacing and sensing functions of the pacemaker were observed using electrocardiography, echocardiography, and pacing threshold monitoring. A comprehensive assessment of the treatment efficacy was conducted, encompassing improvements in clinical symptoms, growth and development, as well as the absence of any additional potential complications. The children who did not receive pacemaker implantation were followed up.

RESULTS

Among the four children who successfully received pacemaker implantation, one child who received non-early implantation died. For the remaining three children, the threshold level, amplitude, impedance, and minute ventilation sensor function of the pacemaker were good during the follow-up period, with a heart rate at the pacing rate. The growth and development of the aforementioned patients who received pacemaker implantation demonstrated adherence to the percentile curve, and their motor and cognitive development remained unaffected. However, among the children who did not undergo pacemaker implantation, two experienced death, while three were lost to follow-up, thereby limiting the evaluation of their long-term outcomes.

CONCLUSIONS

Early implantation of an epicardial pacemaker at an early stage in newborns and infants diagnosed with CCAVB can significantly improve clinical symptoms without affecting their growth and development. These data are in line with current literature and suggest that early implantation of an epicardial pacemaker in newborns and infants diagnosed with CCAVB but further studies are needed.

摘要

背景

本文总结了新生儿和婴儿先天性完全性房室传导阻滞(CCAVB)的治疗经验,并探讨了在该人群中使用永久性起搏器植入治疗 CCAVB 的必要性和可行性。

方法

本研究回顾性分析了 2005 年 1 月至 2023 年 3 月期间我院收治的 9 例 CCAVB 患儿的临床资料和随访结果。其中,2 例患儿行早期(1 岁以内)永久性起搏器植入,2 例患儿行非早期(1 岁或以上)植入,5 例患儿未行起搏器植入。术前通过临床症状、心电图和超声心动图等检查明确 CCAVB 诊断。术后通过心电图、超声心动图和起搏阈值监测观察起搏器的起搏和感知功能。综合评估治疗效果,包括临床症状改善、生长发育情况以及有无其他潜在并发症。未行起搏器植入的患儿进行随访。

结果

4 例成功植入起搏器的患儿中,1 例非早期植入患儿死亡。其余 3 例患儿在随访期间起搏器阈值、幅度、阻抗及分钟通气传感器功能良好,起搏心率接近设定频率。植入起搏器患儿的生长发育均遵循百分位曲线,运动及认知发育不受影响。未行起搏器植入的患儿中,2 例死亡,3 例失访,故限制了对其长期结局的评估。

结论

对诊断为 CCAVB 的新生儿和婴儿早期行心外膜起搏器植入能显著改善临床症状,且不影响生长发育。这些数据与现有文献一致,提示对诊断为 CCAVB 的新生儿和婴儿早期行心外膜起搏器植入是可行的,但仍需进一步研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00f6/10664347/ed78e842b175/12872_2023_3620_Fig1_HTML.jpg

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