College of Sports Medicine, Wuhan Sports University, Wuhan, 430079, Hubei Province, China.
Department of Rehabilitation, Zhongda Hospital, Southeast University, Nanjing, 210009, Jiangsu Province, China.
BMC Pulm Med. 2023 Nov 21;23(1):459. doi: 10.1186/s12890-023-02720-0.
Several observational studies have reported an association between hand grip strength (HGS) and pulmonary function (PF). However, causality is unclear. To investigate whether HGS and PF are causally associated, we performed Mendelian randomization (MR) analyses.
We identified 110 independent single nucleotide polymorphisms (SNPs) for right-hand grip strength (RHGS) and 103 independent SNPs for left-hand grip strength (LHGS) at the genome-wide significant threshold (P < 5 × 10) from MRC-IEU Consortium and evaluated these related to PF. MR estimates were calculated using the inverse-variance weighted (IVW) method and multiple sensitivity analyses were further performed.
Genetical liability to HGS was positively causally associated with forced vital capacity (FVC) and forced expiratory volume in one second (FEV1), but not with FEV1/FVC. In addition, there was positive causal association between RHGS and FVC (OR=1.519; 95% CI, 1.418-1.627; P=8.96E-33), and FEV1 (OR=1.486; 95% CI, 1.390-1.589; P=3.19E-31); and positive causal association between LHGS and FVC (OR=1.464; 95% CI, 1.385-1.548; P=2.83E-41) and FEV1 (OR=1.419; 95% CI, 1.340-1.502; P=3.19E-33). Nevertheless, no associations were observed between RHGS and FEV1/FVC (OR=0.998; 95% CI, 0.902-1.103; P=9.62E-01) and between LHGS and FEV1/FVC (OR=0.966; 95% CI, 0.861-1.083; P=5.52E-01). Similar results were shown in several sensitivity analyses.
Our study provides support at the genetic level that HGS is positively causally associated with FVC and FEV1, but not with FEV1/FVC. Interventions for HGS in PF impairment deserve further exploration as potential indicators of PF assessment.
几项观察性研究报告称，握力（HGS）与肺功能（PF）之间存在关联。然而，因果关系尚不清楚。为了研究 HGS 和 PF 是否存在因果关联，我们进行了孟德尔随机化（MR）分析。
我们从 MRC-IEU 联盟中确定了 110 个用于右手握力（RHGS）和 103 个用于左手握力（LHGS）的全基因组显著阈值（P < 5×10）的独立单核苷酸多态性（SNP），并评估了这些 SNP 与 PF 的相关性。使用逆方差加权（IVW）方法计算 MR 估计值，并进一步进行了多种敏感性分析。
HGS 的遗传易感性与用力肺活量（FVC）和一秒用力呼气量（FEV1）呈正相关，但与 FEV1/FVC 无关。此外，RHGS 与 FVC（OR=1.519；95%CI，1.418-1.627；P=8.96E-33）和 FEV1（OR=1.486；95%CI，1.390-1.589；P=3.19E-31）之间存在正相关因果关系；LHGS 与 FVC（OR=1.464；95%CI，1.385-1.548；P=2.83E-41）和 FEV1（OR=1.419；95%CI，1.340-1.502；P=3.19E-33）之间也存在正相关因果关系。然而，在 RHGS 与 FEV1/FVC（OR=0.998；95%CI，0.902-1.103；P=9.62E-01）和 LHGS 与 FEV1/FVC（OR=0.966；95%CI，0.861-1.083；P=5.52E-01）之间没有观察到关联。在几种敏感性分析中也得到了类似的结果。
本研究在遗传水平上提供了支持，表明 HGS 与 FVC 和 FEV1 呈正相关，但与 FEV1/FVC 无关。在 PF 受损的情况下，干预 HGS 值得进一步探索，作为 PF 评估的潜在指标。
