Zhuo Chengui, Zhao Jianqiang, Wang Qiqi, Lin Zujin, Cai Haipeng, Pan Huili, Chen Lei, Jin Xiangyu, Jin Hong, Xu Longwei, Tao Xiyan
Department of Cardiology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, China.
Department of Cardiology, The Fourth Affiliated Hospital of Zhejiang University School of Medicine, Yiwu, China.
Front Cardiovasc Med. 2022 Aug 4;9:930077. doi: 10.3389/fcvm.2022.930077. eCollection 2022.
Several observational studies have identified that handgrip strength was inversely associated with cardiovascular diseases (CVDs). Nevertheless, causality remains controversial. We conducted Mendelian randomization (MR) analysis to examine whether handgrip strength and risk of CVDs are causally associated.
We identified 160 independent single nucleotide polymorphisms (SNPs) for right-hand grip strength and 136 independent SNPs for left-hand grip strength at the genome-wide significant threshold ( < 5 × 10) from UK Biobank participants and evaluated these in relation to risk of CVDs. MR estimates was calculated using the inverse-variance weighted (IVW) method and multiple sensitivity analysis was further conducted.
Genetical liability to handgrip strength was significantly associated with coronary artery disease (CAD) and myocardial infarction (MI), but not stroke, hypertension, or heart failure. Additionally, there was significant association between right-hand grip strength and atrial fibrillation (OR, 0.967; 95% CI, 0.950-0.984; = 0.000222), however, suggestive significance was found between left-hand grip strength and atrial fibrillation (OR, 0.977; 95% CI, 0.957-0.998; = 0.033). Results were similar in several sensitivity analysis.
Our study provides support at the genetic level that handgrip strength is negatively associated with the risk of CAD, MI, and atrial fibrillation. Specific handgrip strength interventions on CVDs warrant exploration as potential CVDs prevention measures.
多项观察性研究已证实握力与心血管疾病（CVD）呈负相关。然而，因果关系仍存在争议。我们进行了孟德尔随机化（MR）分析，以检验握力与CVD风险之间是否存在因果关联。
我们从英国生物银行参与者中，在全基因组显著阈值（<5×10）下确定了160个用于右手握力的独立单核苷酸多态性（SNP）和136个用于左手握力的独立SNP，并评估了它们与CVD风险的关系。使用逆方差加权（IVW）方法计算MR估计值，并进一步进行了多重敏感性分析。
握力的遗传易感性与冠状动脉疾病（CAD）和心肌梗死（MI）显著相关，但与中风、高血压或心力衰竭无关。此外，右手握力与心房颤动之间存在显著关联（OR，0.967；95%CI，0.950 - 0.984；P = 0.000222），然而，左手握力与心房颤动之间存在提示性意义（OR，0.977；95%CI，0.957 - 0.998；P = 0.033）。在多项敏感性分析中结果相似。
我们的研究在基因水平上支持握力与CAD、MI和心房颤动风险呈负相关。针对CVD的特定握力干预措施作为潜在的CVD预防措施值得探索。
