• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用链脲佐菌素诱导的糖尿病肾病小鼠模型的实验室和临床发现。

Laboratory and clinical findings in mouse models of diabetic nephropathy induced with streptozotocin.

机构信息

Medical Student, HangTuah University, Surabaya, Indonesia.

Department of Hyperbaric, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia.

出版信息

BMC Endocr Disord. 2023 Nov 22;23(1):254. doi: 10.1186/s12902-023-01504-1.

DOI:10.1186/s12902-023-01504-1
PMID:37990213
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10664383/
Abstract

BACKGROUND

Diabetic nephropathy (DN) represents a microvascular complication of diabetes mellitus (DM). Despite the increasing incidence and prevalence of DN, conservative therapy only reduces risk factors and hemodialysis. This research aimed at finding DN animal model that can be tried to be given an alternative treatment. DN was assessed by evaluating body weight, blood glucose, proteinuria, and kidney histopathology.

METHODS

Wistar novergicus male rats were induced with 75 mg of streptozotocin per kg BW to obtain a diabetic nephropathy model. The 18 rats were divided into 2 groups consisting of 9 rats in the negative group (G0) and 9 rats in the positive group (G1). Indicators of body weight, blood glucose levels, urine protein and kidney histopathology determine the incidents of DN animal models.

RESULT

Rats induced using 75 mg of streptozotocin per kg body weight (BW) indicated weight loss, increased blood glucose, urine protein levels and histopathological features of DN.

CONCLUSION

Seventy-five mg of streptozotocin per kg BW can induce a diabetic nephropathy animal model in Wistar norvegicus rats.

摘要

背景

糖尿病肾病（DN）是糖尿病（DM）的一种微血管并发症。尽管 DN 的发病率和患病率不断上升，但保守治疗仅能降低风险因素和进行血液透析。本研究旨在寻找可尝试替代治疗的 DN 动物模型。通过评估体重、血糖、蛋白尿和肾脏组织病理学来评估 DN。

方法

使用 75mg/kg BW 的链脲佐菌素诱导雄性 Wistar norvegicus 大鼠建立糖尿病肾病模型。将 18 只大鼠分为两组，每组 9 只，分别为阴性组（G0）和阳性组（G1）。体重、血糖水平、尿蛋白和肾脏组织病理学等指标确定 DN 动物模型的发生率。

结果

使用 75mg/kg BW 的链脲佐菌素诱导的大鼠体重减轻、血糖升高、尿蛋白水平升高，并出现 DN 的组织病理学特征。

结论

75mg/kg BW 的链脲佐菌素可诱导 Wistar norvegicus 大鼠发生糖尿病肾病动物模型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef39/10664383/06e5b789e04d/12902_2023_1504_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef39/10664383/6e54a3dfecdb/12902_2023_1504_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef39/10664383/4231e157e416/12902_2023_1504_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef39/10664383/53e5453a6099/12902_2023_1504_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef39/10664383/7417b67e9603/12902_2023_1504_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef39/10664383/24aee07951ef/12902_2023_1504_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef39/10664383/56e275ec6fba/12902_2023_1504_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef39/10664383/f357c4c366bd/12902_2023_1504_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef39/10664383/bfa2a5d70f20/12902_2023_1504_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef39/10664383/06e5b789e04d/12902_2023_1504_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef39/10664383/6e54a3dfecdb/12902_2023_1504_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef39/10664383/4231e157e416/12902_2023_1504_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef39/10664383/53e5453a6099/12902_2023_1504_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef39/10664383/7417b67e9603/12902_2023_1504_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef39/10664383/24aee07951ef/12902_2023_1504_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef39/10664383/56e275ec6fba/12902_2023_1504_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef39/10664383/f357c4c366bd/12902_2023_1504_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef39/10664383/bfa2a5d70f20/12902_2023_1504_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef39/10664383/06e5b789e04d/12902_2023_1504_Fig9_HTML.jpg

相似文献

1
Laboratory and clinical findings in mouse models of diabetic nephropathy induced with streptozotocin.用链脲佐菌素诱导的糖尿病肾病小鼠模型的实验室和临床发现。
BMC Endocr Disord. 2023 Nov 22;23(1):254. doi: 10.1186/s12902-023-01504-1.
2
Combination of telmisartan with sildenafil ameliorate progression of diabetic nephropathy in streptozotocin-induced diabetic model.替米沙坦与西地那非联合使用可改善链脲佐菌素诱导的糖尿病模型中糖尿病肾病的进展。
Biomed Pharmacother. 2016 Jul;81:136-144. doi: 10.1016/j.biopha.2016.04.001. Epub 2016 Apr 16.
3
Effects of HuoxueJiangtang decoction alone or in combination with metformin on renal function and renal cortical mRNA expression in diabetic nephropathy rats.活血降糖方单独及联合二甲双胍对糖尿病肾病大鼠肾功能及肾皮质 mRNA 表达的影响。
Pharm Biol. 2020 Dec;58(1):1123-1130. doi: 10.1080/13880209.2020.1844242.
4
Benazepril hydrochloride improves diabetic nephropathy and decreases proteinuria by decreasing ANGPTL-4 expression.盐酸贝那普利通过降低血管生成素样蛋白4（ANGPTL-4）的表达来改善糖尿病肾病并减少蛋白尿。
BMC Nephrol. 2017 Oct 4;18(1):307. doi: 10.1186/s12882-017-0724-1.
5
Relationships between diabetic nephropathy and insulin resistance, inflammation, Trx, Txnip, CysC and serum complement levels.糖尿病肾病与胰岛素抵抗、炎症、Trx、Txnip、CysC 和血清补体水平的关系。
Eur Rev Med Pharmacol Sci. 2020 Nov;24(22):11700-11706. doi: 10.26355/eurrev_202011_23815.
6
The effects of pentoxifylline on diabetic renal changes in streptozotocin-induced diabetes mellitus.己酮可可碱对链脲佐菌素诱导的糖尿病中糖尿病性肾脏改变的影响。
Ren Fail. 2004 Nov;26(6):597-605. doi: 10.1081/jdi-200038329.
7
Anti-diabetic and renoprotective effects of aliskiren in streptozotocin-induced diabetic nephropathy in female rats.阿利吉仑对链脲佐菌素诱导的雌性大鼠糖尿病肾病的抗糖尿病和肾脏保护作用。
Naunyn Schmiedebergs Arch Pharmacol. 2016 Dec;389(12):1315-1324. doi: 10.1007/s00210-016-1299-2. Epub 2016 Sep 9.
8
Perindopril treatment in streptozotocin induced diabetic nephropaty.培哚普利治疗链脲佐菌素诱导的糖尿病肾病。
Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2013;34(1):99-108.
9
The role of oxidative stress in streptozotocin-induced diabetic nephropathy in rats.氧化应激在链脲佐菌素诱导的大鼠糖尿病肾病中的作用。
Arch Endocrinol Metab. 2016 Oct;60(5):443-449. doi: 10.1590/2359-3997000000188. Epub 2016 Aug 25.
10
Effect of Alpina oxyphylla extract on streptozotocin-induced kidney injure via regulating TGF-β1 and MyD88.阿尔卑斯唐松草提取物通过调节 TGF-β1 和 MyD88 对链脲佐菌素诱导的肾损伤的影响。
BMC Complement Med Ther. 2020 Jul 13;20(1):217. doi: 10.1186/s12906-020-02972-x.

本文引用的文献

1
Up-Date on Diabetic Nephropathy.糖尿病肾病的最新进展
Life (Basel). 2022 Aug 8;12(8):1202. doi: 10.3390/life12081202.
2
Microtubule associated protein 4 phosphorylation-induced epithelial-to-mesenchymal transition of podocyte leads to proteinuria in diabetic nephropathy.微管相关蛋白 4 磷酸化诱导足细胞上皮-间质转化导致糖尿病肾病蛋白尿。
Cell Commun Signal. 2022 Jul 28;20(1):115. doi: 10.1186/s12964-022-00883-7.
3
could alleviate streptozotocin-induced diabetic nephropathy in rats by activating Nrf2 signaling.可以通过激活 Nrf2 信号通路来减轻链脲佐菌素诱导的大鼠糖尿病肾病。
Sci Prog. 2022 Apr-Jun;105(2):368504221102751. doi: 10.1177/00368504221102751.
4
Recent therapeutic targets in diabetic nephropathy.糖尿病肾病的近期治疗靶点。
Int J Clin Pract. 2021 Nov;75(11):e14650. doi: 10.1111/ijcp.14650. Epub 2021 Aug 10.
5
Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment.糖尿病肾病：发病机制、诊断和治疗的挑战。
Biomed Res Int. 2021 Jul 8;2021:1497449. doi: 10.1155/2021/1497449. eCollection 2021.
6
Might hyperbaric oxygen therapy (HBOT) reduce renal injury in diabetic people with diabetes mellitus? From preclinical models to human metabolomics.高压氧疗法（HBOT）能否降低糖尿病患者的肾损伤？从临床前模型到人类代谢组学。
Cell Stress Chaperones. 2018 Nov;23(6):1143-1152. doi: 10.1007/s12192-018-0944-8. Epub 2018 Oct 30.
7
Diabetic Kidney Disease: Challenges, Progress, and Possibilities.糖尿病肾病：挑战、进展与可能。
Clin J Am Soc Nephrol. 2017 Dec 7;12(12):2032-2045. doi: 10.2215/CJN.11491116. Epub 2017 May 18.
8
Diabetic nephropathy - complications and treatment.糖尿病肾病——并发症与治疗
Int J Nephrol Renovasc Dis. 2014 Oct 15;7:361-81. doi: 10.2147/IJNRD.S40172. eCollection 2014.
9
Trends in prevalence of diabetes in Asian countries.亚洲国家糖尿病患病率的变化趋势。
World J Diabetes. 2012 Jun 15;3(6):110-7. doi: 10.4239/wjd.v3.i6.110.
10
Pathologic classification of diabetic nephropathy.糖尿病肾病的病理分类。
J Am Soc Nephrol. 2010 Apr;21(4):556-63. doi: 10.1681/ASN.2010010010. Epub 2010 Feb 18.