Department of Neurosurgery, Hualien Tzu Chi Hospital, Hualien, 970, Taiwan.
Institute of Medical Sciences, Tzu Chi University, Hualien, 970, Taiwan.
Regen Med. 2023 Dec;18(12):907-911. doi: 10.2217/rme-2023-0120. Epub 2023 Nov 22.
Spinal cord injury (SCI) can cause severe disability. Several clinical trials of stem-cell based therapies are ongoing. We describe our experience of bone marrow mesenchymal stem cell (BMSC) therapy in a patient with complete SCI in the chronic stage. A 25-year-old man with complete SCI at T6 level presented with paraplegia for 5 years. We transplanted autologous BMSCs intramedullary. After 12 months follow-up, his Barthel index score was noticeably improved from severe to moderate dependency, and the sensation level improved from T7 to S5, but no improvement of motor function. Autologous BMSCs are potentially safe for patients with complete SCI in the chronic stage and may improve neurological function and quality of life.
脊髓损伤（SCI）可导致严重残疾。目前正在进行几项基于干细胞的治疗的临床试验。我们描述了一位慢性期完全性 SCI 患者骨髓间充质干细胞（BMSC）治疗的经验。一位 25 岁的男性，T6 水平完全性 SCI，截瘫 5 年。我们进行了自体 BMSC 经椎管内移植。随访 12 个月后，他的巴氏指数评分从严重依赖显著改善至中度依赖，感觉平面从 T7 改善至 S5，但运动功能无改善。对于慢性期完全性 SCI 患者，自体 BMSCs 具有潜在的安全性，并可能改善神经功能和生活质量。
