Isogai E, Isogai H, Ito N
Zentralbl Bakteriol Mikrobiol Hyg A. 1986 Nov;262(4):438-47. doi: 10.1016/s0176-6724(86)80137-7.
Growth of leptospiras in the presence of diphenylamine (DPA) caused a decrease in the content of leptospiral lipopolysaccharide (LPS). In association with this decrease of LPS, leptospiras became susceptible to anti-leptospiral action of normal rabbit serum (NRS), leptospiricidal action of antibody and complement, and killing by phagocytes. DPA-treated leptospiras were eliminated rapidly from the blood of infected mice and could not grow in the animals.
在二苯胺（DPA）存在的情况下，钩端螺旋体的生长导致钩端螺旋体脂多糖（LPS）含量降低。随着LPS含量的这种降低，钩端螺旋体变得易受正常兔血清（NRS）的抗钩端螺旋体作用、抗体和补体的杀钩端螺旋体作用以及吞噬细胞的杀伤作用影响。经DPA处理的钩端螺旋体迅速从感染小鼠的血液中清除，并且无法在动物体内生长。
