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评价经尿道双极前列腺剜除术与耻骨后开放前列腺切除术治疗大于 80cc 前列腺增生的疗效和患者满意度:一项前瞻性随机研究。

Evaluation of bipolar Transurethral Enucleation and Resection of the Prostate in terms of efficiency and patient satisfaction compared to retropubic open prostatectomy in prostates larger than 80 cc. A prospective randomized study.

机构信息

Urology Department, Faculty of Medicine, Al-Azhar University, Cairo.

出版信息

Arch Ital Urol Androl. 2023 Nov 21;95(4):11629. doi: 10.4081/aiua.2023.11629.

DOI:10.4081/aiua.2023.11629
PMID:37990975
Abstract

OBJECTIVES

To compare the outcomes of bipolar Transurethral Enucleation Resection of the Prostate (TUERP) and simple retropubic prostatectomy in patients with prostate volumes larger than 80 cc.

PATIENTS AND METHODS

A prospective randomized study included all patients amenable to surgeries for benign prostate hyperplasia (BPH) with prostate size over 80 cc at a tertiary care hospital between January 2020 to February 2022. Bipolar TUERP and Retropubic open prostatectomy techniques were compared regarding patients' demographics, intraoperative parameters, outcomes, and peri-operative complications.

RESULTS

Ninety patients were included in our study and randomly assigned to bipolar TUERP (Group 1 = 45 patients) and retropubic open prostatectomy (Group 2 = 45 patients). The TUERP group demonstrated significantly lower operative time (77 ± 11 minutes vs. 99 ± 14 minutes, p < 0.001), hemoglobin drop (median = 1.1 vs. 2.5, p < 0.001), and resected tissue weight (71 ± 6.6 cc vs. 84.5 ± 10.6 cc, p < 0.001). Postoperatively, the TUERP group demonstrated significantly lower catheter time (median = 2 vs. 7 days, p < 0.001) and less hospital stay. IPSS, Qmax, and patient satisfaction were better in the TUERP group within six months of surgery. We reported 90-day complications after TUERP in 13.3% of patients compared to 17.8% after retropubic prostatectomy, with a statistically insignificant difference. Urethral stricture predominated after TUERP, while blood transfusion dominated in retropubic prostatectomy.

CONCLUSIONS

The present study found that TUERP had equivalent efficacy and safety to open retropubic prostatectomy for patients with BPH and prostate volumes > 80 ml.

摘要

目的

比较经尿道前列腺双极电切术(TUERP)和耻骨后前列腺切除术治疗前列腺体积大于 80cc 的患者的结局。

患者和方法

一项前瞻性随机研究纳入了 2020 年 1 月至 2022 年 2 月期间在一家三级保健医院因前列腺体积大于 80cc 而适合手术治疗良性前列腺增生(BPH)的所有患者。比较了经尿道前列腺双极电切术(TUERP)和耻骨后开放前列腺切除术技术,评估了患者的人口统计学特征、手术参数、结局和围手术期并发症。

结果

我们的研究纳入了 90 例患者,并随机分配至经尿道前列腺双极电切术(TUERP)组(1 组=45 例)和耻骨后开放前列腺切除术(2 组=45 例)。TUERP 组的手术时间明显更短(77±11 分钟比 99±14 分钟,p<0.001)、血红蛋白下降量更小(中位数=1.1 比 2.5,p<0.001)、切除组织重量更轻(71±6.6cc 比 84.5±10.6cc,p<0.001)。术后,TUERP 组的导管留置时间(中位数=2 天比 7 天,p<0.001)和住院时间更短。术后 6 个月,TUERP 组的国际前列腺症状评分(IPSS)、最大尿流率(Qmax)和患者满意度均优于对照组。TUERP 组的 90 天并发症发生率为 13.3%,而耻骨后前列腺切除术组为 17.8%,差异无统计学意义。TUERP 后以尿道狭窄为主,而耻骨后前列腺切除术后以输血为主。

结论

本研究发现,对于前列腺体积大于 80ml 的 BPH 患者,TUERP 与耻骨后开放前列腺切除术的疗效和安全性相当。

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