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[通过过继转移研究葡萄球菌的免疫记忆]

[Immunologic memory for Staphylococcus studied by adoptive transfer].

作者信息

Liashchenko K P, Golovanova T A, Bobrovnik S A

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1986 Oct(10):93-5.

PMID:3799107
Abstract

The basic regularities of the formation and realization of immunological memory to staphylococcal corpuscular antigen were studied in adoptive transfer experiments on CBA mice. The capacity of spleen cells for generating anamnestic response to staphylococci in the body of irradiated syngeneic recipients appeared on day 3 after the immunization of donors. The formation of immunological memory to staphylococci in mice was shown to be directly related to the dose of the antigen. The study also revealed that intact splenocytes did not suppress the realization of immunological memory to staphylococci in the system of adoptive transfer. The conclusion of the absence of the "isogeneic barrier" for memory cells specific to staphylococcal corpuscular antigen was made.

摘要

通过对CBA小鼠进行过继转移实验,研究了对葡萄球菌颗粒抗原免疫记忆形成与实现的基本规律。在给供体免疫后第3天,脾细胞在受照射的同基因受体体内产生对葡萄球菌回忆反应的能力出现。结果表明,小鼠对葡萄球菌免疫记忆的形成与抗原剂量直接相关。该研究还揭示,完整的脾细胞在过继转移系统中不会抑制对葡萄球菌免疫记忆的实现。得出了针对葡萄球菌颗粒抗原特异性记忆细胞不存在“同基因屏障”的结论。

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