Shao Yuting, Hu Xiaole, Wang Yuxi, Shao Yi, Li Luchuan, Zeng Qingdong, Lai Hong, Sheng Lei
Department of Endocrinology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Department of Operating Room, Qilu Hospital of Shandong University, Shandong, China.
Endocr Connect. 2023 Dec 12;13(1). doi: 10.1530/EC-23-0373. Print 2024 Jan 1.
Serum 25-hydroxyvitamin D (25(OH)D) deficiency has been known to be associated with the risk and mortality of several cancers. However, the role of 25(OH)D in papillary thyroid cancer (PTC) remains controversial. This study aimed to investigate the association between 25(OH)D and clinicopathologic features of PTC.
Patients who underwent thyroidectomy were retrospectively reviewed. Serum 25(OH)D levels were measured within a week prior to surgery. The patients were categorized into four quartiles according to season-specific 25(OH)D levels. The association between 25(OH)D levels and clinicopathologic features of PTC was analyzed.
A total of 2932 patients were enrolled in the study. The 25(OH)D levels were significantly higher in patients with lymph node metastasis (LNM; P < 0.001), lateral LNM (P < 0.001), and multifocal tumors (P < 0.001). Compared to the first quartile (Q1) of 25(OH)D level, the third quartile (Q3) and the fourth quartile (Q4) showed an unadjusted OR of 1.36 (95% CI: 1.09-1.69; P = 0.006) and 1.76 (95% CI: 1.42-2.19; P < 0.001) for LNM (P for trend < 0.001), respectively. An increased risk of multifocal tumors was strongly associated with high 25(OH)D concentration (P for trend <0.001). Similar results were obtained after adjusting for confounding factors.
High 25(OH)D levels are associated with aggressive features of PTC, such as lymph node metastasis and multifocality.
血清25-羟维生素D（25(OH)D）缺乏已知与多种癌症的风险和死亡率相关。然而，25(OH)D在甲状腺乳头状癌（PTC）中的作用仍存在争议。本研究旨在探讨25(OH)D与PTC临床病理特征之间的关联。
对接受甲状腺切除术的患者进行回顾性分析。在手术前一周内测量血清25(OH)D水平。根据季节特异性25(OH)D水平将患者分为四个四分位数。分析25(OH)D水平与PTC临床病理特征之间的关联。
共有2932例患者纳入本研究。有淋巴结转移（LNM；P<0.001）、侧方LNM（P<0.001）和多灶性肿瘤的患者25(OH)D水平显著更高（P<0.001）。与25(OH)D水平的第一四分位数（Q1）相比，第三四分位数（Q3）和第四四分位数（Q4）的LNM未调整OR分别为1.36（95%CI：1.09-1.69；P=0.006）和1.76（95%CI：1.42-2.19；P<0.001）（趋势P<0.001）。多灶性肿瘤风险增加与高25(OH)D浓度密切相关（趋势P<0.001）。在调整混杂因素后获得了类似结果。
高25(OH)D水平与PTC的侵袭性特征相关，如淋巴结转移和多灶性。
