Department of Molecular and Biomedical Science, School of Biological Sciences, Research Centre for Infectious Diseases, University of Adelaide, Adelaide, Australia.
Molecular Sciences and Technology, College of Science and Engineering, Flinders University, Adelaide, Australia.
J Bacteriol. 2023 Dec 19;205(12):e0032023. doi: 10.1128/jb.00320-23. Epub 2023 Nov 22.
Bacterial pathogens have vastly distinct sites that they inhabit during infection. This requires adaptation due to changes in nutrient availability and antimicrobial stress. The bacterial surface is a primary barrier, and here, we show that the bacterial pathogen increases its surface decorations when it transitions to an intracellular lifestyle. We also observed changes in bacterial and host cell fatty acid homeostasis. Specifically, intracellular increased the expression of their fatty acid degradation pathway, while the host cell lipid pool was significantly depleted. Importantly, bacterial proliferation could be inhibited by fatty acid supplementation of host cells, thereby providing novel insights into the possible link between human malnutrition and susceptibility to .
细菌病原体在感染过程中栖息在截然不同的部位。这需要适应，因为营养物质的可用性和抗菌应激会发生变化。细菌表面是主要的屏障，在这里，我们发现当细菌病原体转变为细胞内生活方式时，它会增加其表面装饰物。我们还观察到细菌和宿主细胞脂肪酸动态平衡的变化。具体来说，细胞内的细菌增加了其脂肪酸降解途径的表达，而宿主细胞的脂质库则明显减少。重要的是，通过向宿主细胞补充脂肪酸可以抑制细菌的增殖，从而为人类营养不良与易感性之间的可能联系提供新的见解。
