Huisman A, Aarnoudse J G
Acta Obstet Gynecol Scand. 1986;65(6):605-8. doi: 10.3109/00016348609158396.
Second-trimester hemoglobin (Hb) concentration was measured in 1535 pregnancies. Mean Hb concentration was significantly increased in women who developed pregnancy-induced hypertension (PIH) in the last trimester before the 37th week (p less than 0.01). A similar trend was also observed in nulliparous women who gave birth to infants with a birthweight below the 10th percentile, especially in smokers. The highest Hb concentrations were found in women with both PIH and intra-uterine growth retardation (IUGR). These findings are in agreement with previous observations in smaller studies and indicate that a reduced plasma volume may already be present in the second trimester, before PIH and/or IUGR appear.
对1535例妊娠进行了孕中期血红蛋白（Hb）浓度测量。在妊娠37周前最后一个孕期发生妊娠高血压综合征（PIH）的女性中，平均Hb浓度显著升高（p<0.01）。在分娩出生体重低于第10百分位数婴儿的初产妇中也观察到类似趋势，尤其是吸烟者。PIH和宫内生长受限（IUGR）并存的女性中Hb浓度最高。这些发现与之前较小规模研究的观察结果一致，表明在PIH和/或IUGR出现之前，孕中期可能已经存在血浆容量减少的情况。
