Rasmussen S, Oian P
Department of Obstetrics and Gynecology, University Hospital of Tromso, Norway.
Gynecol Obstet Invest. 1998;46(4):225-31. doi: 10.1159/000010039.
The aim of the study was to assess the effect of cigarette smoking on first- to second-trimester change in hemoglobin (Hb) concentration and the presence of pregnancy-induced hypertension (PIH). In smokers and non-smokers the mean difference between the first- and second-trimester Hb concentration was 1.5-1.6 and 1.3 g/dl, respectively (p < 0.0001). The incidence of PIH among smokers and non-smokers was 4.0 and 7.5%, respectively (p < 0.0001). The risk of PIH increased with increasing second-trimester Hb. After adjustment for factors including previous pregnancies, maternal age and weight gain by logistic regression analysis, the increased Hb declined and the decreased incidence of PIH in smokers persisted.
本研究的目的是评估吸烟对孕早期至孕中期血红蛋白（Hb）浓度变化及妊娠高血压（PIH）发生情况的影响。吸烟者和非吸烟者孕早期和孕中期Hb浓度的平均差异分别为1.5 - 1.6 g/dl和1.3 g/dl（p < 0.0001）。吸烟者和非吸烟者中PIH的发生率分别为4.0%和7.5%（p < 0.0001）。PIH的风险随着孕中期Hb的升高而增加。经逻辑回归分析对包括既往妊娠、产妇年龄和体重增加等因素进行校正后，吸烟者中升高的Hb有所下降，而PIH发生率降低的情况仍然存在。
