Department of Animal Physiology, Faculty of Science, Charles University, Albertov 6, 128 00, Prague, Czech Republic.
Department of Veterinary Physiology and Biochemistry, SBBUVAS, Sakrand, 67210, Sindh, Pakistan.
Biol Trace Elem Res. 2024 Sep;202(9):3999-4006. doi: 10.1007/s12011-023-03966-9. Epub 2023 Nov 22.
The present study evaluated the effects of dietary selenium yeast (SY) on the brain, CSF, and blood of 30 crossbreed goats (5-6 months of age) of both sexes. After the acclimatization of 2 weeks, they were randomly separated into two groups (n = 15) named C and SY groups. The C group received only a basal diet, while SY received a basal diet along with 0.3 mg/kg/diet of SY (Sel-Plex®) in total 0.035 mg/kg/diet of SY for 10 weeks. Se concentration (µg /g dry weight) in 15 different parts of the goat's brain was accessed, and results showed that the highest concentration was found in the occipital cerebrum (322.0 ± 6.146), whereas the lowest concentration was found in the midbrain (10.33 ± 0.232). Besides, the oxidative biomarkers including GSH (12.13 ± 0.191), GSH-Px (206.7 ± 2.362), GST (23.80 ± 0.279), CAT (14.80 ± 0.279), and SOD (152.5 ± 9.540) were increased in SY as compared to GSH (8.200 ± 0.144), GSH-Px (112.9 ± 1.183), GST (18.93 ± 0.284), CAT (12.53 ± 0.215), and SOD (109.0 ± 1.966) of C. The level of cholesterol was also significantly decreased in the serum of the SY group (84.87 ± 0.960) as compared to C (110.5 ± 0.592). In addition, the cholesterol level in CSF decreased significantly in SY (0.3567 ± 0.016) as compared to C (0.509 ± 0.009). The current research suggests that SY supplementation has improved the brain's antioxidant status, blood biochemistry, and cholesterol levels in both serum and CSF of goats.
本研究评估了饲粮酵母硒（SY）对 30 只杂交山羊（5-6 月龄，雌雄各半）大脑、脑脊液和血液的影响。适应期 2 周后，将它们随机分为两组（n=15），分别命名为 C 组和 SY 组。C 组仅接受基础日粮，而 SY 组在基础日粮中添加 0.3mg/kg/d SY（Sel-Plex®），SY 总摄入量为 0.035mg/kg/d，持续 10 周。检测了山羊大脑 15 个不同部位的硒浓度（µg/g 干重），结果表明，最高浓度出现在枕叶大脑（322.0±6.146），而最低浓度出现在中脑（10.33±0.232）。此外，与 GSH（8.200±0.144）、GSH-Px（112.9±1.183）、GST（18.93±0.284）、CAT（12.53±0.215）和 SOD（109.0±1.966）相比，SY 组的 GSH（12.13±0.191）、GSH-Px（206.7±2.362）、GST（23.80±0.279）、CAT（14.80±0.279）和 SOD（152.5±9.540）等氧化生物标志物水平均升高。SY 组血清胆固醇水平也显著降低（84.87±0.960），与 C 组（110.5±0.592）相比。此外，SY 组脑脊液中的胆固醇水平也显著降低（0.3567±0.016），与 C 组（0.509±0.009）相比。本研究表明，SY 补充剂提高了山羊大脑的抗氧化状态、血液生化和血清及脑脊液中的胆固醇水平。
