• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
From collective health to "personalized" medicine: bioethical challenges in preimplantation genetic testing from a North-South perspective.从群体健康到“个性化”医学:南北视角下的胚胎植入前遗传学检测所带来的生物伦理挑战。
Salud Colect. 2023 Sep 12;19:e4481. doi: 10.18294/sc.2023.4481.
2
Preimplantation genetic testing in assisted reproduction.辅助生殖中的植入前基因检测。
Minerva Obstet Gynecol. 2023 Jun;75(3):260-272. doi: 10.23736/S2724-606X.21.04805-3. Epub 2021 Jul 30.
3
Ready for polygenic risk scores? An analysis of regulation of preimplantation genetic testing in European countries.准备好迎接多基因风险评分了吗?欧洲国家植入前基因检测监管情况分析。
Hum Reprod. 2024 May 2;39(5):1117-1130. doi: 10.1093/humrep/deae049.
4
Preimplantation genetic testing for more than one genetic condition: clinical and ethical considerations and dilemmas.针对多种遗传疾病的胚胎植入前遗传学检测:临床与伦理考量及困境。
Hum Reprod. 2019 Jun 4;34(6):1146-1154. doi: 10.1093/humrep/dez059.
5
Preimplantation Genetic Testing for Genetic Diseases: Limits and Review of Current Literature.胚胎植入前遗传学检测用于遗传疾病:限制与当前文献回顾。
Genes (Basel). 2023 Nov 17;14(11):2095. doi: 10.3390/genes14112095.
6
Reproductive Choices in Haemoglobinopathies: The Role of Preimplantation Genetic Testing.血红蛋白病中的生殖选择:植入前基因检测的作用
Genes (Basel). 2025 Mar 21;16(4):360. doi: 10.3390/genes16040360.
7
Non-invasive preimplantation genetic testing (niPGT): the next revolution in reproductive genetics?非侵入性胚胎植入前遗传学检测(niPGT):生殖遗传学的下一次革命?
Hum Reprod Update. 2020 Jan 1;26(1):16-42. doi: 10.1093/humupd/dmz033.
8
Preimplantation genetic testing: A remarkable history of pioneering, technical challenges, innovations, and ethical considerations.胚胎植入前遗传学检测:一段开拓性、技术挑战、创新和伦理考量的卓越历史。
Mol Reprod Dev. 2024 Jan;91(1):e23727. doi: 10.1002/mrd.23727.
9
Improved clinical utility of preimplantation genetic testing through the integration of ploidy and common pathogenic microdeletions analyses.通过整合倍性和常见致病性微缺失分析提高植入前基因检测的临床实用性。
Hum Reprod. 2023 Apr 3;38(4):762-775. doi: 10.1093/humrep/dead033.
10
"Are we not going too far?": Socio-ethical considerations of preimplantation genetic testing using polygenic risk scores according to healthcare professionals.“我们是不是走得太远了?”:医疗保健专业人员对使用多基因风险评分进行植入前基因检测的社会伦理考量
Soc Sci Med. 2024 Feb;343:116599. doi: 10.1016/j.socscimed.2024.116599. Epub 2024 Jan 17.

本文引用的文献

1
The clinical application of polygenic risk scores: A points to consider statement of the American College of Medical Genetics and Genomics (ACMG).多基因风险评分的临床应用:美国医学遗传学与基因组学学会(ACMG)的一份要点声明
Genet Med. 2023 May;25(5):100803. doi: 10.1016/j.gim.2023.100803. Epub 2023 Mar 15.
2
Addressing ethical issues related to prenatal diagnostic procedures.解决与产前诊断程序相关的伦理问题。
Matern Health Neonatol Perinatol. 2023 Feb 3;9(1):1. doi: 10.1186/s40748-023-00146-4.
3
Assisted reproductive technologies in Latin America: the Latin American Registry, 2019.拉丁美洲辅助生殖技术:2019 年拉丁美洲注册中心报告。
JBRA Assist Reprod. 2022 Nov 9;26(4):637-658. doi: 10.5935/1518-0557.20220034.
4
The False Dawn of Polygenic Risk Scores for Human Disease Prediction.人类疾病预测中多基因风险评分的虚假曙光
J Pers Med. 2022 Jul 31;12(8):1266. doi: 10.3390/jpm12081266.
5
A review of normative documents on preimplantation genetic testing: Recommendations for PGT-P.对植入前遗传学检测规范性文件的回顾:PGT-P 建议。
Genet Med. 2022 Jun;24(6):1165-1175. doi: 10.1016/j.gim.2022.03.001. Epub 2022 Mar 24.
6
The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice.多基因风险评分在胚胎植入前遗传学检测中的应用:一种未经证实、不道德的做法。
Eur J Hum Genet. 2022 May;30(5):493-495. doi: 10.1038/s41431-021-01000-x. Epub 2021 Dec 17.
7
Celebrating 30 years of ART in Latin America; and the 2018 report.庆祝拉丁美洲抗逆转录病毒治疗 30 年;以及 2018 年报告。
JBRA Assist Reprod. 2021 Oct 4;25(4):617-639. doi: 10.5935/1518-0557.20210055.
8
Why do people seek out polygenic risk scores for complex disorders, and how do they understand and react to results?为什么人们会寻求复杂疾病的多基因风险评分,以及他们如何理解和应对这些结果?
Eur J Hum Genet. 2022 Jan;30(1):81-87. doi: 10.1038/s41431-021-00929-3. Epub 2021 Jul 19.
9
Problems with Using Polygenic Scores to Select Embryos.使用多基因评分选择胚胎存在的问题。
N Engl J Med. 2021 Jul 1;385(1):78-86. doi: 10.1056/NEJMsr2105065.
10
Preimplantation Genetic Testing for Monogenic Disorders.胚胎植入前遗传学检测用于单基因疾病。
Genes (Basel). 2020 Jul 31;11(8):871. doi: 10.3390/genes11080871.

从群体健康到“个性化”医学:南北视角下的胚胎植入前遗传学检测所带来的生物伦理挑战。

From collective health to "personalized" medicine: bioethical challenges in preimplantation genetic testing from a North-South perspective.

机构信息

Doctora en Psicología. Investigadora Asistente, Consejo Nacional de Investigaciones Científicas y Técnicas, con sede en Facultad de Psicología, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

Doctora en Ciencias Biológicas. Becaria postdoctoral, Consejo Nacional de Investigaciones Científicas y Técnicas, con sede en Facultad de Filosofía y Letras, Universidad de Buenos Aires. Jefa de Trabajos Prácticos, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

出版信息

Salud Colect. 2023 Sep 12;19:e4481. doi: 10.18294/sc.2023.4481.

DOI:10.18294/sc.2023.4481
PMID:37992285
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11930333/
Abstract

This article examines the scope and limitations of the precision medicine paradigm and its relationship with the collective health approach. To that end, it takes preimplantation genetic testing (PGT) as a paradigmatic example of technologies aimed at the "individualization" of health processes. In this regard, we review the characteristics and scientific and regulatory foundations of PGT technologies in Argentina, and discuss the next steps for their bioethical analysis. More specifically, we shed light on some of the conditions for their implementation from a north-south perspective. We propose three themes or problematic aspects as a synthesis of our analysis, related to biases in the production of knowledge, the values and interests underlying its uses, and the underlying epistemological assumptions of these technologies. Throughout the article, we review these dilemmas and suggest some issues that should be taken into account in future research.

摘要

本文探讨了精准医学范式的范围和局限性及其与集体健康方法的关系。为此,它以着床前遗传学检测(PGT)为例,说明了旨在“个体化”健康过程的技术。在这方面,我们回顾了阿根廷 PGT 技术的特点和科学及监管基础,并讨论了对其进行生物伦理分析的下一步措施。更具体地说,我们从南北角度出发,探讨了其实施的一些条件。我们提出了三个主题或有问题的方面作为我们分析的综合,这些主题与知识生产中的偏见、其使用所依据的价值观和利益以及这些技术的潜在认识论假设有关。在整篇文章中,我们审查了这些困境,并提出了一些在未来研究中应考虑的问题。