Department of Neurology, University of Colorado School of Medicine, Aurora, CO, United States of America.
Department of Neurology, University of Colorado School of Medicine, Aurora, CO, United States of America; Division of Infectious Diseases, University of Colorado School of Medicine, Aurora, CO, United States of America; Department of Epidemiology, Colorado School of Public Health, Aurora, CO, United States of America.
J Neuroimmunol. 2023 Dec 15;385:578249. doi: 10.1016/j.jneuroim.2023.578249. Epub 2023 Nov 19.
Cerebrospinal fluid (CSF) eosinophilia is associated with a narrow differential, primarily including parasitic and fungal infections, neoplasm, and chemical meningitis. It has rarely been reported in neuroinflammatory conditions including as a finding of CSF cytology in two autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy cases. Here we describe a case of autoimmune GFAP astrocytopathy with classic clinical and radiographic features as well as presence of eosinophils in the CSF. This case highlights a potential association of eosinophils in the CSF with autoimmune GFAP astrocytopathy, which may suggest its inclusion in the differential diagnosis of eosinophilic meningitis, encephalitis, or myelitis.
脑脊液（CSF）嗜酸性粒细胞增多与一个狭窄的鉴别诊断相关，主要包括寄生虫和真菌感染、肿瘤和化学性脑膜炎。它很少在神经炎症性疾病中报道，包括在两个自身免疫性胶质纤维酸性蛋白（GFAP）星形细胞瘤病例的脑脊液细胞学检查中发现。在这里，我们描述了一例具有典型临床和影像学特征以及 CSF 中嗜酸性粒细胞的自身免疫性 GFAP 星形细胞瘤病例。该病例突出了 CSF 中的嗜酸性粒细胞与自身免疫性 GFAP 星形细胞瘤之间的潜在关联，这可能提示将其纳入嗜酸性粒细胞性脑膜炎、脑炎或脊髓炎的鉴别诊断中。
