Department of Neurology and Institute of Neurology of First Affiliated Hospital, Institute of Neuroscience, and Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, 350005, China.
Department of Gastrointestinal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China.
J Infect Chemother. 2024 Jun;30(6):544-547. doi: 10.1016/j.jiac.2023.11.017. Epub 2023 Nov 21.
Streptococcus suis is a pathogen of emerging zoonotic diseases and meningoencephalitis is the most frequent clinical symptom of S. suis infection in humans. Rapid diagnosis of S. suis meningoencephalitis is critical for the treatment of the disease. While the current routine microbiological tests including bacterial culture and gram staining are poorly sensitive, diagnosis of S. suis meningoencephalitis by metagenomic next-generation sequencing (mNGS) has been rarely reported. Here, we report a 52-year-old female pork food producer with a broken finger developed S. suis meningoencephalitis. After her admission, no pathogenic bacteria were detected through bacterial culture and Gram staining microscopy in the cerebrospinal fluid obtained via lumbar puncture. However, mNGS identified the presence of S. suis in the sample. mNGS is a promising diagnostic tool for rapid diagnosis of rare infectious diseases in the central nervous system.
猪链球菌是一种新兴的人畜共患病病原体，脑膜炎是人类感染猪链球菌最常见的临床症状。快速诊断猪链球菌脑膜炎对于疾病的治疗至关重要。虽然目前的常规微生物学检测，包括细菌培养和革兰氏染色，灵敏度较差，但宏基因组下一代测序（mNGS）诊断猪链球菌脑膜炎的报道很少。在这里，我们报告了一例 52 岁的女性猪肉食品生产者，她的手指受伤后发展为猪链球菌脑膜炎。她入院后，通过腰椎穿刺获得的脑脊液经细菌培养和革兰氏染色显微镜检查均未发现致病菌。然而，mNGS 检测到样本中存在猪链球菌。mNGS 是一种很有前途的诊断工具，可快速诊断中枢神经系统罕见的传染病。
