Department of Food Science and Technology, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran; Department of Pharmaceutical Technology, University of Innsbruck, Institute of Pharmacy, Center for Chemistry and Biomedicine, Innrain 80-82, 6020 Innsbruck, Austria.
Department of Food Science and Technology, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran.
J Pharm Sci. 2024 May;113(5):1228-1238. doi: 10.1016/j.xphs.2023.11.019. Epub 2023 Nov 20.
Quercetin (Q) has many potential health benefits, but its low stability limits its use in functional foods and pharmaceuticals. The low stability of quercetin is a challenge that needs to be addressed to fully realize its therapeutic potential. The purpose of this study was therefore to design a proper carrier based on porous starch (PS) and inulin (IN) in order to improve the stability of Q. The scanning electron microscopy (SEM) images denoted that the Q molecules were adsorbed in the PS pores and partially adhered to the surface of the granules. Both types of the wall material could remarkably enhance the protection of Q against thermal and light degradation. The retention index of Q under different environmental conditions was higher for the PS:IN-Q than PS-Q. The results of Fourier transform infrared spectroscopy (FT-IR) revealed that Q interacted with the wall materials through non-covalent bonds. X-ray diffraction (XRD) also confirmed the encapsulation of Q in the wall materials. The bonding between Q and the hydrogen groups of starch compacted the crystalline regions and increased the relative crystallinity in PS-Q and PS:IN-Q. The DPPH and ABTS scavenging activities of the microcapsules containing the PS and IN were higher than those of free Q. Examination of the in-vitro release profile indicated that the Q release rate was lower from the PS:IN-Q microcapsules (21.6%) than from the PS-Q ones (33.7%). Our findings highlight the significant potential of this novel biopolymer mixture (PS/IN) as a promising wall material for the protection and delivery of bioactive compounds.
槲皮素 (Q) 具有许多潜在的健康益处，但由于其稳定性低，限制了它在功能性食品和药物中的应用。提高槲皮素的稳定性是一个需要解决的挑战，以充分发挥其治疗潜力。因此，本研究旨在设计一种基于多孔淀粉 (PS) 和菊粉 (IN) 的合适载体，以提高 Q 的稳定性。扫描电子显微镜 (SEM) 图像表明，Q 分子被吸附在 PS 孔中，并部分附着在颗粒表面。这两种壁材都能显著提高 Q 对热和光降解的保护作用。在不同环境条件下，PS:IN-Q 中 Q 的保留指数高于 PS-Q。傅里叶变换红外光谱 (FT-IR) 的结果表明 Q 通过非共价键与壁材相互作用。X 射线衍射 (XRD) 也证实了 Q 被包埋在壁材中。Q 与淀粉氢基团之间的键合压缩了结晶区，增加了 PS-Q 和 PS:IN-Q 的相对结晶度。含有 PS 和 IN 的微胶囊的 DPPH 和 ABTS 清除活性高于游离 Q。体外释放曲线的检查表明，PS:IN-Q 微胶囊中 Q 的释放速度（21.6%）低于 PS-Q 微胶囊（33.7%）。我们的研究结果突出了这种新型生物聚合物混合物 (PS/IN) 作为一种有前途的保护和输送生物活性化合物的壁材的巨大潜力。
