基本螺旋-环-螺旋（bHLH）-PAS 转录因子和共激活因子中的 PER-ARNT-SIM（PAS）结构域：结构与机制。
Per-ARNT-Sim (PAS) Domains in Basic Helix-Loop-Helix (bHLH)-PAS Transcription Factors and Coactivators: Structures and Mechanisms.
机构信息
Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
出版信息
J Mol Biol. 2024 Feb 1;436(3):168370. doi: 10.1016/j.jmb.2023.168370. Epub 2023 Nov 20.
Abstract
PAS domains are ubiquitous in biology. They perform critically important roles in sensing and transducing a wide variety of environmental signals, and through their ability to bind small-molecule ligands, have emerged as targets for therapeutic intervention. Here, we discuss our current understanding of PAS domain structure and function in the context of basic helix-loop-helix (bHLH)-PAS transcription factors and coactivators. Unlike the bHLH-PAS domains of transcription factors, those of the steroid receptor coactivator (SRC) family are poorly characterized. Recent progress for this family and for the broader bHLH-PAS proteins suggest that these domains are ripe for deeper structural and functional studies.
摘要
PAS 结构域在生物学中普遍存在。它们在感知和转导各种环境信号方面发挥着至关重要的作用，并且通过其结合小分子配体的能力，已成为治疗干预的靶点。在这里，我们讨论了我们目前对基本螺旋-环-螺旋（bHLH）-PAS 转录因子和共激活子中 PAS 结构域结构和功能的理解。与转录因子的 bHLH-PAS 结构域不同，类固醇受体共激活因子（SRC）家族的 PAS 结构域的特征描述较差。该家族和更广泛的 bHLH-PAS 蛋白的最新进展表明，这些结构域非常适合进行更深入的结构和功能研究。
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