The Romanian Association for Autoimmune Encephalitis, Cluj-Napoca, Romania; Department of Psychiatry, "Iuliu Hațieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Int Rev Neurobiol. 2023;173:1-42. doi: 10.1016/bs.irn.2023.08.009. Epub 2023 Sep 10.
Despite intensive research into the etiopathogenesis of autism spectrum disorder (ASD), limited progress has been achieved so far. Among the plethora of models seeking to clarify how ASD arises, a coherent dopaminergic model was lacking until recently. In 2017, we provided a theoretical framework that we designated "the dopamine hypothesis of ASD". In the meantime, numerous studies yielded empirical evidence for this model. 4 years later, we provided a second version encompassing a refined and reconceptualized framework that accounted for these novel findings. In this chapter, we will review the evidence backing the previous versions of our model and add the most recent developments to the picture. Along these lines, we intend to lay out a comprehensive analysis of the supporting evidence for the dopamine hypothesis of ASD.
尽管自闭症谱系障碍 (ASD) 的发病机制研究已经很深入，但到目前为止，进展仍然有限。在众多试图阐明 ASD 发生机制的模型中，直到最近才出现一个连贯的多巴胺能模型。2017 年，我们提供了一个理论框架，我们称之为“ASD 的多巴胺假说”。与此同时，许多研究为该模型提供了经验证据。4 年后，我们提供了第二个版本，其中包含一个经过改进和重新概念化的框架，以解释这些新发现。在本章中，我们将回顾支持我们模型的前两个版本的证据，并为该模型增加最新的发展。通过这种方式，我们旨在对 ASD 的多巴胺假说的支持证据进行全面分析。
