寄生虫原生生物中的铜 - 一个迄今为止被忽视的毒力因子。
Copper in parasitic protists - a hitherto neglected virulence factor.
机构信息
Department of Parasitology, Faculty of Science, Charles University, BIOCEV, Vestec, Czech Republic.
Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA, USA.
出版信息
Trends Parasitol. 2024 Jan;40(1):5-9. doi: 10.1016/j.pt.2023.10.003. Epub 2023 Nov 21.
Copper plays a fundamental role in aerobic metabolism, but its role is double-edged, given its toxicity. Our understanding of copper metabolism in parasites remains rudimentary, despite its significance in virulence. Here we discuss how parasitic protists control copper homeostasis and show the potential key players identified by our bioinformatic analysis.
铜在需氧代谢中起着基本作用，但由于其毒性，其作用具有两面性。尽管铜在寄生虫的毒力中具有重要意义，但我们对寄生虫中铜代谢的理解仍然很初步。在这里，我们讨论了寄生原生动物如何控制铜的体内平衡，并展示了我们的生物信息学分析确定的潜在关键因素。
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